Results 121 to 130 of about 62,115 (257)

Inhibition of the MER tyrosine kinase ameliorates pulmonary fibrosis by suppressing macrophage M2 polarisation and osteopontin signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose The MER proto‐oncogene tyrosine kinase (MERTK) has been implicated in the pathogenesis of pulmonary fibrosis (PF), and MERTK inhibition has been shown to ameliorate PF. However, the mechanisms remain unclear. Here, we have investigated how MERTK inhibition attenuates bleomycin (BLM)‐induced PF in mice and to elucidate the ...
Juan Li, Xiangsheng Yang, Xiao Xiao Tang
wiley   +1 more source

A Transgenic Rat Model of DXd ADC‐Related Interstitial Pneumonitis for Mechanistic and Translational Research

Cancer Science, EarlyView.
hTROP2 Tg rats exhibit key pathological and transcriptomic features of DXd ADC‐related ILD, supporting their utility as a translational model. Rat, alveolus, antibody illustrations were adapted from NIAID NIH BioArt Source. ABSTRACT Deruxtecan‐based antibody‐drug conjugates (DXd ADCs) provide substantial clinical benefit across multiple malignancies ...
Kazuyoshi Kumagai, Yuma Nagai, Yuji Shirai, Kazunori Fujimoto, Masako Imaoka, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals

Brain Research Bulletin
Chronic pain is a universal public health problem with nearly one third of global human involved, which causes significant distressing personal burden. After painful stimulus, neurobiological changes occur not only in peripheral nervous system but also ...
Ying-Yi Lu, Chia-Yang Lin, Chun-Ching Lu, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin Wu   +6 more
doaj   +1 more source

Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review. [PDF]

IJU Case Rep
ABSTRACT Introduction Sertoli cell tumors are rare testicular sex cord‐stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an APC mutation. Case Presentation A 27‐year‐old man with familial adenomatous polyposis (FAP) presented with painless right scrotal ...
Obayashi K, Terasaki M, Hasegawa H, Mikami H, Yanagi M, Takeda H, Endo Y, Toyama Y, Ohashi R, Akatsuka J.   +9 more
europepmc   +2 more sources

CHEMICAL CLEAVAGE OF BLEOMYCIN TO BLEOMYCINIC ACID AND SYNTHESIS OF NEW BLEOMYCINS

The Journal of Antibiotics, 1973
T, Takita, A, Fujii, T, Fukuoka, H, Umezawa   +3 more
openaire   +3 more sources

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source

Alogliptin/Amentoflavone Combination Mitigates Bleomycin-Induced Lung Fibrosis: The Role of Oxidative Stress, TXNIP-Mediated Pyroptosis, and Autophagy/Apoptosis Balance

Pharmaceuticals
Background/Objectives: Bleomycin is an antineoplastic antibiotic used in the management of various malignancies. Nevertheless, its benefits are constrained by the development of pulmonary fibrosis.
Hanan Abdelmawgoud Atia, Hemat A. Elariny, Gehad M. Subaiea, Asmaa Saleh, Amany M. Khalifa, Doaa Hellal, Kareem M. Younes, Ahmed M. Kabel   +7 more
doaj   +1 more source

Chemistry of bleomycin. XVI. Epi-bleomycin.

The Journal of Antibiotics, 1976
YASUHIKO MURAOKA, HIROKO KOBAYASHI, AKIO FUJII, MAMORU KUNISHIMA, TOSHIYUKI FUJII, YUYA NAKAYAMA, TOMOHISA TAKITA, HAMAO UMEZAWA   +7 more
openaire   +3 more sources

hUC-MSC down-regulate bleomycin-induced lung fibrosis.

, 2018
Collagen content in mouse lungs 8 days (A-D), 14 days (E-H) and 21 days (I-L) after endotracheal injection of sterile saline (saline) or bleomycin (bleomycin), the latter also followed by intravenous infusion of hUC-MSC (bleomycin+hUC-MSC) or sterile ...
Antonella Grieco (5329112), Chiara Capelli (5329100), Mauro Provinciali (448980), Gianluca Moroncini (784833), Gaia Goteri (590527), Eleonora Mondini (5329103), Stefania Saccomanno (567500), Cecilia Tonnini (5329106), Nicoletta Del Papa (5329109), Silvia Agarbati (5329091), Fiorenza Orlando (448979), Chiara Paolini (5329097), Armando Gabrielli (359687), Martino Introna (387266), Silvia Svegliati Baroni (5329094)   +14 more
core   +1 more source

The different face of skin‐rash induced by brentuximab vedotin

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background: Brentuximab vedotin (BV) is a targeted therapy for CD30‐expressing lymphomas, including Hodgkin lymphoma (HL) and cutaneous T‐cell lymphoma (CTCL). While peripheral neuropathy is the most common adverse event, BV‐induced skin rashes are less frequent and not well characterized.
Alessandro Pileri, Tullio Brunetti, Serena Rupoli, Gianluca Cafasso, Corrado Zengarini, Staphano Cedirian, Federico Bardazzi, Cosimo Misciali, Michela Starace, Claudio Agostinelli, Gaia Goteri, Erika Morsia   +11 more
wiley   +1 more source