Results 121 to 130 of about 53,368 (224)

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor renewal in idiopathic pulmonary fibrosis. [PDF]

J Clin Invest
Zhang X, Liu X, Qiao Y, Rabata A, Liu N, Yao C, Parimon T, Chen D, Hogaboam CM, Chen P, Stripp BR, Gardell SJ, Jiang D, Noble PW, Liang J.   +14 more
europepmc   +1 more source

Liquid embolic agents-a practical overview. [PDF]

CVIR Endovasc
Cannavale A, Ratnam L, Mahnken A, Alonso-Burgos A, Hernandez EE, Lanza C, Loffroy R.   +6 more
europepmc   +1 more source

Lung Microbiome Dysbiosis in Pulmonary Fibrosis Induced by Multi-Walled Carbon Nanotubes and Bleomycin in Rats. [PDF]

Medicina (Kaunas)
Cho WS, Thillaichidambaram M, Jeon S, Kim GR, Lee SU, Lee SH, Kim YJ, Lee ES, Kim Y, Kang D, Kim SY.   +10 more
europepmc   +1 more source

The cyclin‐dependent kinase inhibitor KIP‐RELATED PROTEIN 6 promotes stem cell death upon DNA damage in Arabidopsis roots

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY Maintenance of genome integrity is essential for plant growth and survival. Plants have evolved specialised DNA damage responses that coordinate DNA repair, cell cycle arrest and stem cell‐specific cell death. However, the mechanism through which damaged stem cells are selectively eliminated remains unclear.
Toshiki Wada, Ayako N. Sakamoto, Masaaki Umeda, Naoki Takahashi   +3 more
wiley   +1 more source

Disulfiram Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis with Reduced Endothelial Pyroptosis and Neutrophil Adhesion. [PDF]

J Inflamm Res
Sun CY, Yang WL, Shen HC, Yu WK, Chen WC, Yang KY.   +5 more
europepmc   +1 more source

Chronic Cholestatic Liver Disease Induced by Larval Ascariasis: Novel Insights Into Immune‐Mediated Pathogenesis and Hepatic Fibrosis in Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Liver alterations induced by single infection (SI) or reinfection (RE) with 250 or 2500 Ascaris suum eggs in mice. Histological analysis shows inflammatory cell infiltration (eosinophils, lymphocytes, macrophages, and neutrophils), fibrotic areas, and bile duct proliferation in infected animals compared with uninfected controls.
Jorge Lucas Nascimento Souza, Chiara Cássia Oliveira Amorim, Ana Rafaela Antunes‐Porto, Fernanda Rezende Souza, Evelyn Ane Oliveira, Izabela da Silva Oliveira, Isabela de Brito Duval, Andressa Mariana Saldanha‐Elias, Marcelo Eduardo Cardozo, Ramayana Morais de Medeiros Brito, Luisa Mourão Dias Magalhães, Geovanni Dantas Cassali, Neima Briggs, Ricardo Toshio Fujiwara, Remo Castro Russo, Guilherme Grossi Lopes Cançado, Lilian Lacerda Bueno   +16 more
wiley   +1 more source

AKT Signaling Differentially Regulates the Expression of Two Evolutionarily Conserved <i>Wnt5a</i> Isoforms in Lung Mesenchymal Cells. [PDF]

Cells
Smith SM, Zhou JC, Zhang H, Kibe R, Chwa J, Qu Z, Zhou B, Minoo P, Li C.   +8 more
europepmc   +1 more source

DNA Scission by Non‐Histidine Amino‐Terminal Cu(II) and Ni(II) Binding‐Like Peptides

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
Non‐His amino‐terminal Cu(II) and Ni(II) binding (ATCUN)‐like peptides containing Ala and Asp instead of His form Cu(II)/Ni(II) complexes and induce oxidative plasmid DNA scission. The metallopeptides bind preferentially to AT‐rich DNA regions and promote nicking and linearization in the presence of Cu(II) and ascorbate. These findings demonstrate that
Lena K. Müller, Hanna Zhdanova, Ivan N. Unksov, Alexander Gräwe, Joshua Stahl, Viktor Stein, Daniel Tietze, Alesia A. Tietze   +7 more
wiley   +1 more source

Repurposing the MEK inhibitor binimetinib as a dual anti-inflammatory and antifibrotic agent in pulmonary fibrosis. [PDF]

J Thorac Dis
Zhang Y, Chen Q, Shi Y, Li Z, Chen R, Wang M, Shao C, Gao S, Zhou H, Huang H.   +9 more
europepmc   +1 more source