Results 101 to 110 of about 53,368 (224)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Real‐World Evidence of Treatment Patterns, Time to Real‐World Progression, and Overall Survival of Patients With Testicular Germ Cell Tumors Receiving Palliative Chemotherapy in the United States

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Introduction Patients with relapsed/refractory (R/R) testicular germ cell tumor (GCT) progressing after salvage chemotherapy only have palliative therapeutic options. Real‐world data on this population are needed. Methods Adult men with testicular GCT receiving palliative chemotherapy in the United States were identified in the Komodo Research
Darren R. Feldman, Patrick Gagnon‐Sanschagrin, Jessica Maitland, Kana Yokoji, Annie Guérin, Victoria Guan, George Joseph   +6 more
wiley   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

DRAM1‐defined autophagy‐JAK‐STAT‐Tregs axis drives immunosuppression and predicts immunotherapy response in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu, Hailing Yang, Jingjing Cao, Min Yang, Wanqiao Cao, Yonglei Liu, Yunfeng Cheng, Fanli Hua   +7 more
wiley   +1 more source

Studies of photochemical internalisation: mechanisms and strategies in cancer therapeutics

, 2010
Photochemical internalisation (PCI) is a technique which enhances targeted drug delivery using light in combination with a photosensitiser. It is a modification of photodynamic therapy (PDT) which involves sub-lethal photodynamic treatment to modify ...
Wang, T.-W.
core  

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

Modulation of Ferroptosis Biomarkers by Thinned Apple Polyphenols Extract in Acute and Chronic Lung Injuries

eFood, Volume 7, Issue 3, June 2026.
Thinned apple polyphenols (TAP) extract reduced ferroptosis in acute and chronic lung injuries. TAP activated Nrf2 and modulated key biomarkers (MDA, NOX4, GPX4, FTH1), leading to decreased inflammation and fibrosis. These findings suggest TAP as a potential therapeutic approach for lung injury through ferroptosis regulation. ABSTRACT Acute and chronic
Rosalba Siracusa, Alessia Arangia, Marika Cordaro, Roberta Fusco, Salvatore Cuzzocrea, Giancarlo Aldini, Daniela Impellizzeri, Rosanna Di Paola, Ramona D'Amico   +8 more
wiley   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, Volume 3, Issue 2, Page 163-184, June 2026.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Targeted LNP-mediated delivery of VE-cadherin mRNA reduces vascular hyperpermeability in vivo. [PDF]

Blood Adv
Leo L, Papp TE, Chen CC, Pham J, Jeong S, Halilovic F, Thompson J, Akyianu A, Zeng J, Rompolas P, Marcos-Contreras OA, Parhiz H.   +11 more
europepmc   +1 more source

Exploring the Nutraceutical Potential of Achillea millefolium L.: Phytochemical Composition, Biological Activities, and Industrial Applications

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed, Muhammad Tauseef Sultan, Ahmad Mujtaba Noman, Hassan Raza, Hagar M. Mohamed, Nimra Anees, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Entessar Al Jbawi, Ehab M. Mostafa, Samy Selim, Ayman Salama, Mohamed A. Abdelgawad   +14 more
wiley   +1 more source