Results 91 to 100 of about 62,115 (257)

The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats

Pulmonary Medicine, 2016
The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin 40, and bleomycin
Nergiz H. Turgut, Haki Kara, Sahende Elagoz, Koksal Deveci, Huseyin Gungor, Emre Arslanbas   +5 more
doaj   +1 more source

Exploring the protective effects of Chrysin against bleomycin-induced lung injury and fibrosis: The role of autophagy and IL-33/ST2 [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Bleomycin is an effective antineoplastic agent. However, it induces lung fibrosis. Chrysin, a natural flavone, possesses multiple biological activities, such as antioxidant, anti-inflammatory and anti-cancer. This study investigated whether chrysin could
Abdelhamid, Marwa Nabil, Michel, Haidy E., Tharwat, Esther, Abd Ellah, Mohamed, El-Demerdash, Ebtehal   +4 more
doaj   +1 more source

Bleomycin preclinical rat model samples.

, 2019
Bleomycin preclinical rat model samples.
Ron Ammar (33236), John Ryan Thompson (6612638), Pitchumani Sivakumar (6612635), Gabor Jarai (410769)   +3 more
core   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

hUC-MSC down-regulate bleomycin-induced lung inflammation.

, 2018
Histology of mouse lungs 8 days (A-D), 14 days (E-H) and 21 days (I-L) after endotracheal injection of sterile saline (saline) or bleomycin (bleomycin), the latter also followed by intravenous infusion of hUC-MSC (bleomycin+hUC-MSC) or sterile saline ...
Antonella Grieco (5329112), Chiara Capelli (5329100), Mauro Provinciali (448980), Gianluca Moroncini (784833), Gaia Goteri (590527), Eleonora Mondini (5329103), Stefania Saccomanno (567500), Cecilia Tonnini (5329106), Nicoletta Del Papa (5329109), Silvia Agarbati (5329091), Fiorenza Orlando (448979), Chiara Paolini (5329097), Armando Gabrielli (359687), Martino Introna (387266), Silvia Svegliati Baroni (5329094)   +14 more
core   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

BLEOMYCIN-INDUCED REVERSIBLE ACUTE INTERSTITIAL PNEUMONIA

, 2017
As of now, about 380 medications are implicated in causing respiratory reactions and most common among that is drug-induced interstitial disease.Oral, parental as well inhalational drugs are known to cause drug-induced interstitial lung disease ...
Balaji Ommurugan, Joseph Thomas, Navin Patil, Amita Priya   +3 more
core   +1 more source

Rational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence

Smart Molecules, EarlyView.
We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang, Feiyi Chu, Bin Feng, Lin Chen, Peili Cen, Jing Wang, Ying Qu, Lu Hong, Fei Wu, Huanfeng Tian, Yanpeng Fang, Yuanjie Chen, Mei Tian, Wenbin Zeng, Hong Zhang, Yan Zhong   +15 more
wiley   +1 more source

Bleomycin treatment of brain tumors: an evaluation

, 2009
Udgivelsesdato: 2009-MarBleomycin has been used in the treatment of brain tumors for over 30 years. Currently, we are evaluating electrochemotherapy (the use of electric pulses to enhance uptake of bleomycin) for patients with secondary brain tumors. We,
Linnert, Mette, Gehl, Julie
core   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source