Results 71 to 80 of about 62,115 (257)

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Ploidy-Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells. [PDF]

Cell Prolif
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Haim-Abadi G, Benvenisty N.
europepmc   +2 more sources

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis [PDF]

, 2011
Background The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of endogenous anti-inflammation, affording
Amílcar S Damazo, Damazo Amílcar S, Damazo, Amilcar S. [UNESP], Perretti, M, Perretti, Mauro, Oliani, Sonia M. [UNESP], Sampaio André LF, Sampaio, Andre L. F., Cintia MAG Nakata, Damazo, AS, Mauro Perretti, Nakata, Cintia M. A. G., Oliani, Sonia M., Roderick J Flower, Sonia M Oliani, Sampaio, ALF, Damazo, Amilcar S., Oliani, SM, Flower, Roderick J., Oliani Sonia M, Flower, RJ, André LF Sampaio, Flower Roderick J, Perretti Mauro, Nakata Cintia MAG, Nakata, CMAG   +25 more
core   +1 more source

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot   +8 more
wiley   +1 more source

Bioanalytical method development and validation of bleomycin sulphate

Journal of Applied Pharmaceutical Research, 2017
Bleomycin is an anti-neoplastic drug that has recently been used for the treatment of vascular anomalies. An expedient method was developed for the determination of plasma bleomycin levels using ion-paired reversed phase high performance liquid ...
Yash Prashar, Harkaran Singh Rana, Souravh Bais   +2 more
doaj  

Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis

Journal of Inflammation
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology related to lung fibrosis, whereas the mechanism that ETS exposure augments pulmonary fibrogenesis is unclear.
Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman   +3 more
doaj   +1 more source

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

Respiratory Research, 2005
Background In the present study, by comparing the responses in wild-type mice (WT) and mice lacking (KO) the inducible (or type 2) nitric oxide synthase (iNOS), we investigated the role played by iNOS in the development of on the lung injury caused by ...
Crimi Nunzio, Gili Elisa, Frasca Giuseppina, Sortino Maria, Mazzon Emanuela, Failla Marco, Di Paola Rosanna, Cuzzocrea Salvatore, Genovese Tiziana, Caputi Achille P, Vancheri Carlo   +10 more
doaj   +1 more source

Analogues of Bleomycin:  Synthesis of Conformationally Rigid Methylvalerates

, 2016
Several conformationally rigid analogues of the methylvalerate subunit contained within the linker domain of the antitumor antibiotic bleomycin have been prepared. These compounds have been protected in a fashion suitable for the solid-phase synthesis of
Sidney M. Hecht (1305729), Michael J. Rishel (1320666)   +1 more
core   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source