Results 71 to 80 of about 45,095 (219)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Improving the Understanding of Late Effects of Testicular Cancer in Adolescent and Young Adult Survivors: TRANSCEND‐XR

Andrology, EarlyView.
ABSTRACT Background Testicular cancer (TC) is the most common malignancy amongst adolescents and young adults (AYAs) aged 15–39 years assigned male at birth. Survivors often experience late effects of treatment and report unmet supportive care needs.
Mohamad M. Saab, Josephine Hegarty, Jack P. Gleeson, David Murphy, Sheena McHugh, Frances Shiely, Aileen Murphy, Ann Kirby, Ida J. Korfage, Sophie Terhaard, Agnes van der Heide, Johannes Sivesgaard, Matias Katajavaara Seidler, Anna Patrikidou, Davor Ježek, Lynda Corrigan, Patrice Kearney Sheehan, Daniele Raggi, Alison Reid, Michal Chovanec, Patrizia Gianntempo, Jourik A. Gietema, Justine Fleur van der Feen, Francisco Lupiáñez‐Villanueva, Ana Roca‐Umbert, Joanne Reid, Paulo Alves, Joana Soares, Karen Galvin, Michal Kubo, Maria O'Malley   +30 more
wiley   +1 more source

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study

Dermatology Practical & Conceptual, 2017
Background: Numerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result.
Paola Pasquali, Azael Freites-Martinez, Salvador Gonzalez, Enrico P. Spugnini, Alfonso Baldi   +4 more
doaj   +1 more source

Bleomycin-induced modulations of PARP 1 activity, NAD+ and PARG content in rat lung nuclei

Regulatory Mechanisms in Biosystems
Bleomycin-induced lung pathology in rodents is a well recognized animal model widely used for evaluation of new therapeutic approaches in treatment of lung inflammation and fibrotic diseases.
I. G. Artsruni, A. L. Asatryan, K. S. Matinyan   +2 more
doaj   +1 more source

Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta‐analysis

BJU International, EarlyView.
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa, Ali Amiri, Sanchit Kaushal, Emma Wilson, Isabelle Tan, Robert J. Hamilton   +5 more
wiley   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, EarlyView.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Photoactivity of bleomycin.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1983
The anticancer drug, bleomycin, has recently been shown to be light-sensitive by a number of research groups. This photosensitivity extends to its complexes with iron(II), copper(II), cobalt(III) and DNA. Nicking of DNA by photoactivated bleomycin occurs at lower concentrations than under dark conditions.
openaire   +3 more sources