Results 51 to 60 of about 60,523 (282)
Drug Delivery, 2019 Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this
Kristoffer K. Hendel +6 more
doaj +1 more source
The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis.
PLoS ONE, 2021 The primary flavonoid, pinocembrin, is thought to have a variety of medical uses which relate to its reported anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer properties.
Habtamu B Derseh +7 more
doaj +1 more source
Kinetics of Intraparenchymal Mononuclear Cells in A Murine Model of Pulmonary Fibrosis Induced by Bleomycin [PDF]
, 1994 Bleomycin (BLM), an anti-tumor drug, has been observed to cause interstitial pneumonia followed by subsequent fibrosis. In order to elucidate the cellular mechanism in the fibrotic process, we examined inflammatory cells in the lungs of mice after ...
Kadota, Jun-Ichi +5 more
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Delayed onset bleomycin-induced pneumonitis
, 2005 We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer.
Uzel, B +7 more
core +1 more source
Advanced Science, EarlyView.Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi +8 more
wiley +1 more source
Cell Transplantation, 2012 Since current treatments for both acute and chronic lung diseases are less than ideal, there has been recent interest in the use of cell-based therapies for inflammatory lung disease. Specifically, human amnion epithelial cells (hAECs) have been shown to
Sean V. Murphy +6 more
doaj +1 more source
CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation
Advanced Science, EarlyView.CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu +6 more
wiley +1 more source
Chinese Journal of Plastic and Reconstructive Surgery, 2022 Background: Venous malformations (VMs) are the most common low-flow vascular malformations. Although various sclerosants are effective, their relative effects have not yet been well established.
Wei Lu +3 more
doaj +1 more source
The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis
, 2023 Amrita Vats,1 Pankaj Chaturvedi2 1Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, IL, 60612, USA; 2Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801 ...
Vats A, Chaturvedi P
core
Advanced Science, EarlyView.During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum +13 more
wiley +1 more source