Results 61 to 70 of about 97,876 (294)

The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis.

PLoS ONE, 2021
The primary flavonoid, pinocembrin, is thought to have a variety of medical uses which relate to its reported anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer properties.
Habtamu B Derseh, Jason Q D Goodger, Jean-Pierre Y Scheerlinck, Chrishan S Samuel, Ian E Woodrow, Enzo A Palombo, Alistair Cumming, Ken Snibson   +7 more
doaj   +1 more source

Cumulative cardiotoxic effect of bleomycin in experiment

Journal of Education, Health and Sport, 2021
The aim of the study was to evaluate the cumulative toxic effect of bleomycin under experimental conditions Material and Methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021.
A. Gozhenko, O. Bestanchuk, O. Kaschenko, T. Narbutova   +3 more
doaj   +1 more source

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
A Collins, A Cougnoux, AO Brachmann, BR Stern, Bradley S. Moore, CA Brotherton, CA Brotherton, CM Woo, D Payros, E Buc, EP Balskus, EP Rogakou, G Cuevas-Ramos, G Sharon, HB Bode, I Cho, J Chen, JA Stubbe, JC Arthur, Jennifer Y. H. Lai, Jie Li, JK Nicholson, JP Nougayrède, KJ Humphreys, KK Khanna, KS Chaturvedi, L Zha, L Zha, LB Schultz, LC Colis, LF Povirk, M Olier, M Pitie, MI Vizcaino, MI Vizcaino, MR Wilson, MS Donia, MS Donia, MS Melvin, N Bossuet-Greif, N Bossuet-Greif, NS Guntaka, P Engel, P Tripathi, Pei-Yuan Qian, RM Bleich, RM Burger, S Borah, S Tomkovich, Shaun M. K. McKinnie, T Faïs, T Pérez-Berezo, T Secher, TC Holmes, V Bondarev, Wei-Peng Zhang, Wenjun Zhang, Wenlong Cai, X Bian, X Bian, Y Pommier, YA Chan, Z-R Li, Z-R Li, Zhong-Rui Li   +64 more
core   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51

Molecular Medicine
Background Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a key factor in the development of ...
Fuqiang Chen, Wenna Zhao, Chenghong Du, Zihan Chen, Jie Du, Meijuan Zhou   +5 more
doaj   +1 more source

Efficacy and safety of sclerosants in the treatment of venous malformations: A network meta-analysis of randomized controlled trials

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Background: Venous malformations (VMs) are the most common low-flow vascular malformations. Although various sclerosants are effective, their relative effects have not yet been well established.
Wei Lu, Zhenyu Yang, Zuoliang Qi, Xiaonan Yang   +3 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Soluble Guanylate Cyclase Reduced the Gastrointestinal Fibrosis in Bleomycin-induced Mouse Model of Systemic Sclerosis. [PDF]

, 2021
Yuzuru Yamamoto, T. Okano, Hirotaka Yamada, Kengo Akashi, Sho Sendo, Yo Ueda, Akio Morinobu, Jun Saegusa   +7 more
openalex   +1 more source

Long‐Term Quality of Life in 1777 Persons With Hodgkin Lymphoma and 6166 Matched Comparators

American Journal of Hematology, EarlyView.
ABSTRACT Survival has improved substantially for patients with Hodgkin lymphoma (HL), but long‐term quality of life (QoL) remains incompletely understood. This was a Danish, nationwide, cross‐sectional study of QoL among persons with a diagnosis of HL matched 1:10 to general population comparators.
Sissel Johanne Godtfredsen, Joachim Baech, Mikkel Porsborg Andersen, Harman Yonis, Paw Jensen, Peter Kamper, Jacob H. Christensen, Rasmus Bo‐Dahl Sørensen, Martin Hutchings, Christian Torp‐Pedersen, Peter Sogaard, Henrik Boggild, Kristian H. Kragholm, Tarec C. El‐Galaly   +13 more
wiley   +1 more source

Spontaneous Pneumomediastinum and Bilateral Pneumothoraces in a Patient with Bleomycin-Induced Pneumonitis

European Journal of Case Reports in Internal Medicine, 2017
Bleomycin lung toxicity is well established and can manifest as bleomycin-induced pneumonitis, but pneumomediastinum and pneumothorax are very rare complications.
Matthieu Barras, Marc Uhlmann
doaj   +1 more source