Results 61 to 70 of about 53,368 (224)

Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats [PDF]

, 2006
Oxidative stress has been implicated in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been studied for prevention and treatment of the disease in animals and humans. We therefore examined whether Ginkgo biloba (Gb),
Yagmurca, M, Erdogan, H, Kotuk, M, Fadillioglu, E, Iraz, M, Ermis, H, Kilic, T   +6 more
core   +1 more source

Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta‐analysis

BJU International, EarlyView.
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa, Ali Amiri, Sanchit Kaushal, Emma Wilson, Isabelle Tan, Robert J. Hamilton   +5 more
wiley   +1 more source

Gossypol prevents bleomycin-induced pulmonary fibrosis.

, 2018
(A) Mice were exposed to 1.5U/kg bleomycin via OA and treated daily with sub-cutaneous injections of the LDHA inhibitor gossypol at 5, 10, or 20 mg/kg until euthanasia at day 21. (B) Collagen levels in the right lung lobes were measured by hydroxyproline
Jennifer L. Judge (5278415), Kristina M. Owens (5278412), R. M. Kottmann (780596), David J. Nagel (5278409), Richard P. Phipps (358002), Ashley Rackow (5278406), Patricia J. Sime (358003)   +6 more
core   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Effects of rapamycin on bleomycin induced fibrosis and autophagy.

, 2013
Hydroxyproline assay measuring lung collagen content demonstrates co-administration of rapamycin and bleomycin protects against fibrosis (*p = 0.003 for control vs. bleomycin; **p = 0.008 for bleomycin vs. rapamycin + bleomycin).
Alexander Geyer (315474), Chang Hyeok An (315476), Danielle Morse (315479), Avignat S. Patel (315473), Ivan O. Rosas (315478), Ling Lin (57361), Jeffrey A. Haspel (315475), Jiaofei Cao (315477)   +7 more
core   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, EarlyView.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis. [PDF]

FASEB J
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Pan X, Yang L, Zhao M, Zhou Y, Xia C, Liu H, Wang Y, Lian H, Li B, Wang L, Yu G.   +10 more
europepmc   +2 more sources

Timecourse of bleomycin-induced lung fibrosis.

, 2013
(A) Timecourse of induction of collagen protein generation in the lungs of mice challenged with intratracheal bleomycin (filled bars) or intratracheal PBS (open bars) as measured by the Sircol Assay (mean±S.E.M. of n = 4–8 mice/group).
Rochelle L. Argentieri (366336), Stephanie M. Warner (375386), Furquan Shaheen (152799), Lynne A. Murray (366328), Tillie L. Hackett (116432), Francis X. Farrell (375388), Darryl A. Knight (107952), Paul Dudas (375387)   +7 more
core   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source