Results 151 to 160 of about 62,115 (257)

DNA damage response associated miRNA dysregulation in Ataxia-telangiectasia. [PDF]

Mol Biol Rep
Iqbal MJ, Bucci C, Ricci A, Morganti G, Khan FI, Khan MJ, Menotta M.   +6 more
europepmc   +1 more source

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

MedComm, Volume 7, Issue 11, November 2026.
In the pulmonary fibrotic microenvironment, mechanical signals activate PIEZO1 to mediate Ca2+ entry into macrophages. Increased CISD1/IP3R activity promotes Ca2+ transfer from the endoplasmic reticulum to mitochondria, leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore (MPTP). Consequently, macrophages
Yungeng Wei, Chao Xie, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

Senescent Fibroblasts Impair B Cell Proliferation via Cell-Cell Contact. [PDF]

Aging Cell
Vezyrgianni K, MacLeod E, Nutley A, Zhu Y, Denton AE.   +4 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Custom bipolar electrode for bleomycin-based electrochemotherapy in patient-derived uveal melanoma <i>in ovo</i> and <i>ex vivo</i>. [PDF]

Front Cell Dev Biol
Anastasova R, Fiorentzis M, Yousefiboroujeni A, Gallo GP, Cadossi M, Dalbah S, Seitz B, Bechrakis NE, Tsimpaki T.   +8 more
europepmc   +1 more source

Rare Feline Gingival Extramedullary Plasmacytoma: Clinical Application of Electrochemotherapy for Local Control

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
This case report describes an aggressive gingival extramedullary plasmacytoma (EMP) with regional lymph node metastasis in a 14‐year‐old cat. As complete surgical excision was unfeasible, three weekly electrochemotherapy (ECT) sessions using intravenous bleomycin were performed for local tumour control.
Seulgi Hwang, Hayoung Ryu, Dong‐In Jung, DoHyeon Yu, Kyu‐Woan Cho, Hyeona Bae   +5 more
wiley   +1 more source

Therapeutic Efficacy of Co-administered WJ-MSCs and Exosomes in a Rat Pulmonary Fibrosis Model. [PDF]

In Vivo
Choi SH, Baek HJ, Kim HS, Choi JW, Min S, Son W.   +5 more
europepmc   +1 more source

Induction of Animal Model of Scleroderma with Repeated Injection of Bleomycin

, 2009
Objective: To induce a mouse model of scleroderma with repeated bleomycin injections for research into human scleroderma at our research laboratory. Methods: The protocol of Yamamoto et al.
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Matrix Metalloproteinase‐8 Deficiency Alters the Balance Between Viral Clearance and Immunopathology in H1N1 Infection

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Mmp‐8 deficiency during H1N1 influenza infection enhances Type I interferon responses, necroptosis‐associated signaling, and adaptive immunity, leading to lower lung viral burden and improved survival, but also amplifies inflammatory lung injury. ABSTRACT Matrix metalloproteinase‐8 (MMP‐8) regulates inflammatory responses, but its contributions to the ...
Xiaoyun Wang, Joselyn Rojas‐Quintero, Duo Zhang, Joaquin Zuñiga, Caroline A. Owen   +4 more
wiley   +1 more source

Flagellate Erythema Induced by a Low Cumulative Dose of Bleomycin: A Case Report. [PDF]

Cureus
Kirby KB, Lam A.
europepmc   +1 more source