Results 91 to 100 of about 729,697 (285)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
3-Homogeneous Groups and Block-Transitive 7–(v, k, 3) Designs
Mathematical and Computational Applications, 2017 The classification of a block-transitive designs is an important subject on algebraic combinatorics. With the aid of MATLAB software, using the classification theorem of 3-homogeneous permutation groups, we look at the classification problem of block ...
Xiaolian Liao, Guohua Chen, Shangzhao Li
doaj +1 more source
Optimal two-level conjoint designs for large numbers of attributes. [PDF]
In this paper, we propose a simple strategy to construct D-, A-, G- and V-optimal two-level multi-attribute designs for rating-based conjoint studies. Our approach combines orthogonal designs and balanced or partially balanced incomplete block designs ...
Goos, P +2 more
core
, 2008 One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L.
A. Betten +40 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Optimal designs for an interference model [PDF]
Kunert and Martin (2000) determined optimal and efficient block designs in a model for field trials with interference effects, for block sizes up to 4. In this paper we use Kushner's method (Kushner, 1997) of finding optimal approximate designs to extend
Kunert, Joachim, Mersmann, Sabine
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Increasing efficiency of preclinical research by group sequential designs.
PLoS Biology, 2017 Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs.
Konrad Neumann +11 more
doaj +1 more source
Comparison Between some Methods of Tackling the Lack of Experimental Units Needed for Application of Factorial Experiments [PDF]
المجلة العراقية للعلوم الاحصائية, 2011 Most of the time the researcher confronts a decrease in the experimental units required when applying a certain design, this problem appears especially when conducting the factorial experiments which mostly need great numbers of experimental units, to ...
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source