Results 71 to 80 of about 102,634 (265)

EXPLORATION OF FINITE GROUP APPROACH IN BALANCED INCOMPLETE BLOCK DESIGN

open access: yesAcademy Journal of Science and Engineering
The development of block designs continues to be an unresolved challenge in combinatorial design, with several forms, the most notable being the balanced incomplete block designs (BIBDs).
Ukeme Akra   +3 more
doaj   +1 more source

3-Homogeneous Groups and Block-Transitive 7–(v, k, 3) Designs

open access: yesMathematical and Computational Applications, 2017
The classification of a block-transitive designs is an important subject on algebraic combinatorics. With the aid of MATLAB software, using the classification theorem of 3-homogeneous permutation groups, we look at the classification problem of block ...
Xiaolian Liao, Guohua Chen, Shangzhao Li
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

New Constructions and Necessary Conditions for 4-GDDs With Block Size 5

open access: yesInternational Journal of Mathematics and Mathematical Sciences
t-v,k,Λ designs are well-known objects of study. Here, we define t-group divisible designs (t-GDDs) and specifically study t-GDDs, where the number of groups are less than the block size. After a short survey of t-GDDs, we will present some examples of 4-
Dinkayehu M. Woldemariam, D. G. Sarvate
doaj   +1 more source

Missing Data Imputation in Balanced Construction for Incomplete Block Designs

open access: yesMathematics
Observational data with massive sample sizes are often distributed on many local machines. From an experimental design perspective, investigators often desire to identify the effect of new treatments (even ML algorithms) on many blocks of experimental ...
Haiyan Yu   +3 more
doaj   +1 more source

Comparison Between some Methods of Tackling the Lack of Experimental Units Needed for Application of Factorial Experiments [PDF]

open access: yesالمجلة العراقية للعلوم الاحصائية, 2011
Most of the time the researcher confronts a decrease in the experimental units required when applying a certain design, this problem appears especially when conducting the factorial experiments which mostly need great numbers of experimental units, to ...
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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