Results 91 to 100 of about 1,775,833 (254)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Adaptive order search and tangent-weighted trade-off for motion estimation in H.264

open access: yesJournal of King Saud University: Computer and Information Sciences, 2018
Motion estimation and compensation play a major role in video compression to reduce the temporal redundancies of the input videos. A variety of block search patterns have been developed for matching the blocks with reduced computational complexity ...
Srinivas Bachu, K. Manjunath Achari
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Analysis, Comparison and Improvement of Block Matching Based Sub-Pixel Motion Measurement Methods for Image Sequences

open access: yes, 2009
In this paper, the sub-pixel motion measurement for image sequences is researched, and an improved two-dimensional distance-similarity measurement based on block matching algorithm is proposed to decrease the huge computational burden of existing ...
Wei YJ(魏阳杰)   +2 more
core  

USING DISPERSION MEASURES FOR DETERMINING BLOCK-SIZE IN-MOTION ESTIMATION

open access: yesDyna, 2012
Las técnicas de compresión de video disminuyen la redundancia temporal entre los fotogramas del video para realizar una compresión eficiente del mismo. Dicha reducción se logra mediante la compensación de movimiento, la cual está basada en la estimación ...
CARLOS MERA, MARIA TRUJILLO
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

VLSI Architectures For Hierarchical Block Matching

open access: yes, 1994
Hierarchical block matching is an efficient motion estimation technique which provides an adaptation of the block size and the search area to the properties of the image.
Chaitali Chakrabarti, Gagan Gupta
core  

AnImprovedVideoDenoisingAlgorithmBasedon3DBlockMatching

open access: yes工程科学与技术, 2014
:The video block-matching and 3-D filtering (VBM3D) algorithm was improved, which had block effect and low-efficiency. A continuous derivative threshold method was introduced during the shrinkage of the coefficient in transform domain, replacing the hard
肖进胜   +4 more
doaj  

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