Results 71 to 80 of about 535,226 (278)

Factoring Block Fiedler Companion Matrices

open access: yes, 2019
When Fiedler published his "A note on Companion matrices" in 2003 in Linear Algebra and its Applications, he could not have foreseen the significance of this elegant factorization of a companion matrix into essentially two-by-two Gaussian transformations, which we will name \emph{(scalar) elementary Fiedler factors}.
G. M. Del Corso   +3 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Equalities and Inequalities for Norms of Block Imaginary Circulant Operator Matrices

open access: yesAbstract and Applied Analysis, 2015
Circulant, block circulant-type matrices and operator norms have become effective tools in solving networked systems. In this paper, the block imaginary circulant operator matrices are discussed.
Xiaoyu Jiang, Kicheon Hong
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Exponentiation Representation of Boolean Matrices in the Framework of Semi-Tensor Product of Matrices

open access: yesIEEE Access, 2019
Semi-tensor product of matrices (STP of matrices) is a new matrix product and has been successfully applied to many fields, especially to logical dynamic systems.
Jumei Yue, Yongyi Yan
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Block Preconditioning Matrices for the Newton Method to Compute the Dominant λ-Modes Associated with the Neutron Diffusion Equation

open access: yesMathematical and Computational Applications, 2019
In nuclear engineering, the λ -modes associated with the neutron diffusion equation are applied to study the criticality of reactors and to develop modal methods for the transient analysis. The differential eigenvalue problem that needs to be
Amanda Carreño   +5 more
doaj   +1 more source

Determinants of block tridiagonal matrices

open access: yesLinear Algebra and its Applications, 2008
8 pages, final form.
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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