Results 71 to 80 of about 1,502,182 (290)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Sparse Recovery With Block Multiple Measurement Vectors Algorithm

IEEE Access, 2019
This paper investigates the performance of the block multiple measurement vectors (BMMV) algorithm in reconstructing block joint sparse matrices. We prove that if 41) obeys block restricted isometry property with 8 K+1 <; Nf +1 , then BMMV perfectly ...
Yanli Shi, Libo Wang, Rong Luo
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Morphology-properties relationship on nanocomposite films based on poly(styrene-block-diene-block-styrene) copolymers and silver nanoparticles

eXPRESS Polymer Letters, 2011
A comparative study on the self-assembled nanostructured morphology and the rheological and mechanical properties of four different triblock copolymers, based on poly(styrene-block-diene-block-styrene) and poly(styrene-block-diene-block-styrene) matrices,
doaj   +1 more source

Link Prediction via Convex Nonnegative Matrix Factorization on Multiscale Blocks

Journal of Applied Mathematics, 2014
Low rank matrices approximations have been used in link prediction for networks, which are usually global optimal methods and lack of using the local information.
Enming Dong, Jianping Li, Zheng Xie
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Precision of methods for calculating identity-by-descent matrices using multiple markers [PDF]

, 2002
A rapid, deterministic method (DET) based on a recursive algorithm and a stochastic method based on Markov Chain Monte Carlo (MCMC) for calculating identity-by-descent (IBD) matrices conditional on multiple markers were compared using stochastic ...
Ricardo Pong-Wong, John A. Woolliams, Sørensen Anders, Woolliams John A, Pong-Wong, Ricardo, Windig, J.J., Sørensen, Anders, Anders Christian S�rensen, Jack J. Windig, Pong Wong, R., John A Woolliams, Jack J Windig, Windig Jack J, Anders Christian Sørensen, Pong-Wong, R.; id_orcid, Anders Sørensen, Windig, Jack, Woolliams, J.A., Woolliams, John, Anders Sørensen, Pong-Wong Ricardo, Sorensen, A.C.   +21 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Factorization of block matrices [PDF]

, 1985
An LU-type factorization theorem due to Elsner and to Gohberg and Goldberg is generalized to block matrices. One form of the general factorization takes the form LMU, where L is block lower-triangular, U is block upper-triangular, and M is a ...
Gohberg, Israel, Ellis, Robert L., Lay, David   +2 more
core   +1 more source