Results 91 to 100 of about 190,703 (303)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Circle grid fractal plate as a turbulent generator for premixed flame: an overview [PDF]
, 2013 This review paper focuses to ascertain a new approach in turbulence generation on the structure of premixed flames and external combustion using a fractal grid pattern.
Othman, Mohd Fahmi +13 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Study on the Arching Shaping and Blockage Mechanism during Silo Discharge Process
Liang you shipin ke-jiIn granular material conveying systems, the smoothness of the unloading process is directly related to operational efficiency. When the ratio of the size of the granular material in the silo to the size of the discharge port is within a specific range ...
LIU Ke-jin +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Actuator Blockage Detection in Milligravity [PDF]
Exploration rover like IDEFIX, the rover of the Martian Moons Exploration Mission (MMX), even when designed with extraordinary diligence, can get stuck in their environment or be affected by other faults.
Holderried, Roman +2 more
core +1 more source
Effect of Blockage on Cylindrical Bridge Pier Local Scour
, 2013 Our understanding of the scouring process and the current empirical design equations is based on laboratory data that may have exceeded acceptable blockage.
D'Alessandro, Carlo
core +1 more source
Pipeline blockage in pneumatic conveying systems
, 2013 Some experts discuss some of the reasons for pipeline blockage in pneumatic conveying systems. There are systems which occasionally fail due to pipeline blockage on start up where the pipeline is left fully or partly filled with product that cannot be ...
McGee, Eddie, McGlinchey, Don
core +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source