Results 91 to 100 of about 451,265 (323)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Onshore versus offshore capacity factor and reliability for wind energy production in Germany: 2010–2022

Energy Science & Engineering
Similarities and differences between the features related to the productivity of onshore and offshore wind energy are developed with the aid of information theory techniques complemented by normal statistics.
E. E. Vogel, G. Saravia, S. Kobe, R. Schuster   +3 more
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Magnetic response of energy levels of superconducting nanoparticles with spin-orbit scattering

, 2015
Discrete energy levels of ultrasmall metallic grains are extracted in single-electron-tunneling-spectroscopy experiments. We study the response of these energy levels to an external magnetic field in the presence of both spin-orbit scattering and pairing
Alhassid, Y., Nesterov, Konstantin N.
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A nonparametric Bayesian approach toward robot learning by demonstration

, 2012
In the past years, many authors have considered application of machine learning methodologies to effect robot learning by demonstration. Gaussian mixture regression (GMR) is one of the most successful methodologies used for this purpose.
Antoniak, Argall, Argall, Billard, Billard, Billard, Billard, Bishop, Blackwell, Blei, Celeux, Chandler, Chatzis, Demiris, Dimitrios Korkinof, Ferguson, Ghahramani, Jordan, Leroux, Lopes, Lopes, Muller, Myersand, Neal, Pearlmutter, Qi, Rasmussen, Schwarz, Sethuraman, Skoglund, Sotirios P. Chatzis, Ude, Vapnik, Walker, Yiannis Demiris, Zegers   +35 more
core   +1 more source

A new permutation test statistic for complete block designs

The Annals of Statistics, 2015
Published in at http://dx.doi.org/10.1214/14-AOS1266 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Samonenko, Inga, Robinson, John
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Bootstrap quantification of estimation uncertainties in network degree distributions

Scientific Reports, 2017
We propose a new method of nonparametric bootstrap to quantify estimation uncertainties in functions of network degree distribution in large ultra sparse networks. Both network degree distribution and network order are assumed to be unknown. The key idea
Yulia R. Gel, Vyacheslav Lyubchich, L. Leticia Ramirez Ramirez   +2 more
doaj   +1 more source