Results 91 to 100 of about 681,701 (257)

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Quantitative PET imaging and modeling of molecular blood-brain barrier permeability

Nature Communications
Neuroimaging of blood-brain barrier permeability has been instrumental in identifying its broad involvement in neurological and systemic diseases. However, current methods evaluate the blood-brain barrier mainly as a structural barrier. Here we developed
Kevin J. Chung, Yasser G. Abdelhafez, Benjamin A. Spencer, Terry Jones, Quyen Tran, Lorenzo Nardo, Moon S. Chen, Souvik Sarkar, Valentina Medici, Victoria Lyo, Ramsey D. Badawi, Simon R. Cherry, Guobao Wang   +12 more
doaj   +1 more source

The Blood-Brain Barrier and Methamphetamine: Open Sesame?

Frontiers in Neuroscience, 2015
The chemical and electrical microenvironment of neurons within the central nervous system is protected and segregated from the circulation by the vascular blood–brain barrier.
Patric eTurowski, Bridget-Ann eKenny
doaj   +1 more source

Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography [PDF]

, 2014
Several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier into the central nervous system. In this article, the performance of three stationary phases for immobilized artificial membrane (IAM ...
De Vrieze, Mike, Lynen, Frederic, Sandra, Patrick, Szucs, Roman, Verzele, Dieter   +4 more
core  

The restorative role of annexin A1 at the blood–brain barrier [PDF]

, 2016
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the
A Aggarwal, A Algotsson, A Armulik, A Cignarella, A Kosicka, A Mahringer, A Moheet, A Montagne, A Parimisetty, A Razmara, A Rosell, A Varatharaj, AB Mitchell, ACC Fonseca da, AJ Farrall, AJ Kiliaan, AK Deo, AK Harris, AM Stranahan, AMS Hartz, AMS Hartz, AP Viggars, AR Nelson, B Engelhardt, B Engelhardt, B Harten van, B Obermeier, B Shao, B Stieger, B-O Nilsson, BJ Andreone, BL Hart, BO Popescu, BT Hawkins, BV Zlokovic, BW Chow, BW McColl, C Derada Troletti, C Joseph, C Knott, C Moran, C Wang, CA Raji, CE Tagoe, CH Hillman, CJ Ek, CN Hall, CV Carman, CW D’Acunto, D Virgintino, D Virgintino, DA Eberhard, DR Thal, DW Kim, DY Yoo, E Brailoiu, E Cristante, E Duinkerken Van, E Maggioli, E Pietronigro, E Solito, E Zenaro, F Boraldi, F Bruschi, F Shimizu, FN Doubal, FNE Gavins, FR Walter, G Cheng, G Cirino, G Fredman, G Han, G Leoni, GG Ortiz, GJ Zoppo del, GL Bowman, H Kang, H Kim, H Qosa, H Sun, H Wang, HJ Haar van de, HK Smith, HS Kang, IA Simpson, J Deng, J Guo, J Satoh, J Tu, J-H Liu, JA Shin, JA Shin, JD Sengillo, JH Heo, JI Alvarez, JM Wardlaw, JS Saczynski, K Monastyrskaya, KM Thrailkill, L Bloemendaal van, L Nathan, L Parente, L Raz, L Sanchez-Covarrubias, L Zhou, L-C Chen, LA Profenno, LB Buckman, LD Ghitescu, M Asgari, M Brkic, M Burek, M Burek, M Elahy, M Fuente de la, M Hellström, M Perretti, M Perretti, M Schwaninger, MA Lopez-Ramirez, MA Lopez-Ramirez, MS Thomsen, N Gorlé, N Muradashvili, N Pannacciulli, N Sumi, NJ Abbott, NJ Abbott, NJ Abbott, NR Saunders, NT Pietrani, P Hu, PJ Magistretti, Q-H Liu, R Deane, R Hallmann, R Sankowski, RC Janzer, RD Bell, RF Haseloff, RH McCusker, RO Roberts, RT Kovacic, S Bena, S Burgmans, S Liebner, S Maysami, S McArthur, S Nadkarni, S Nourshargh, S Ouyang, S Probst-Cousin, S Rius-Pérez, S Suzuki, S Taheri, S Tietz, S Wang, SA Vital, SE Headland, SE Kanoski, SE Moss, SN Cooray, T Nishioku, TL Davidson, TO Price, TS Salameh, WS Hoogenboom, Y Luo, Y Yao, Y-F Tu, YH Jing, YH Lee, Z Tucsek, ZZ Luo   +173 more
core   +4 more sources

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. [PDF]

, 2019
Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal ...
Baranzini, Sergio E, Chan, Jonah R, Fancy, Stephen PJ, Hoi, Kimberly K, Huang, Nanxin, Kim, Kicheol, Niu, Jianqin, Tsai, Hui-Hsin, Xiao, Lan, Yu, Guangdan   +9 more
core  

Computational and in vitro studies of blast-induced blood-brain barrier disruption

, 2015
There is growing concern that blast-exposed individuals are at risk of developing neurological disorders later in life. Therefore, it is important to understand the dynamic properties of blast forces on brain cells, including the endothelial cells that ...
Banks, William A., Cook, David G., Del Razo, Mauricio J., Huber, B. Russell, Leveque, Randall J., Meabon, James S., Morofuji, Yoichi, Mourad, Pierre D., Peskind, Elaine R.   +8 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source