Results 41 to 50 of about 674,412 (272)

The pivotal role of astrocytes in an in vitro stroke model of the blood-brain barrier [PDF]

, 2014
Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could
Anne eMahringer, Carola eFörster, Christoph eRiethmüller, Fabian eGaiser, Jonas eFranz, Winfried eNeuhaus, Winfried eNeuhaus   +6 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

How anti-brain antibodies access the bran and alter behavior and cognition

Journal of Affective Disorders Reports, 2023
Antibodies can target brain antigens but are not harmful to the host unless they enter brain parenchyma. An adult human or mouse has a blood brain barrier that excludes immunoglobulin from entering brain parenchyma.
Betty Diamond, MD
doaj   +1 more source

Additional file 1: of CXCL5 signaling is a shared pathway of neuroinflammation and bloodâ brain barrier injury contributing to white matter injury in the immature brain

, 2016
Supplementary methods. The measurement of cerebral ventricular size and quantification methods for gray matter injury and immunohistochemistry are described in detail here. (DOC 5563Â kb)
Lin-Yu Wang, Tu, Yi-Fang, Yung-Chieh Lin, Chao-Ching Huang   +3 more
openaire   +1 more source

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Molecular Medicine
Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects.
Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek, Fabien Gosselet   +11 more
doaj   +1 more source

Organoid-engineered neurovascular units for drug discovery and neurodegeneration research [PDF]

BioImpacts
The highly selective permeability of the human blood-brain barrier presents a major obstacle to neurological disease modeling. Established 2D cell cultures and animal models are unable to accurately reproduce the physiological and molecular features of ...
Ailar Nakhlband
doaj   +1 more source

Activity of eribulin mesylate in brain metastasis from breast cancer. a stone in a pond? [PDF]

, 2018
Background: Brain metastases develop in approximately 10-25% of patients with metastatic breast cancer (MBC) and are associated with a very poor prognosis.
Catania, G., Cognetti, F., Fabi, A., Gasparro, S., Malaguti, P., Vidiri, A.   +5 more
core   +1 more source