Results 171 to 180 of about 963,269 (378)

Engineered human blood–brain barrier microfluidic model for vascular permeability analyses

Nature Protocols, 2022
Cynthia Hajal, G. Offeddu, Yoojin Shin, Shun Zhang, Olga Morozova, Dean Hickman, Charles G. Knutson, R. Kamm   +7 more
semanticscholar   +1 more source

DNA Barcoding‐Enabled Tracking of Lipid Nanoparticles: Drug‐Loading‐Dependent Biodistribution and Tumor Microenvironment Targeting

Advanced Healthcare Materials, EarlyView.
In this study, lipid nanoparticles are tracked in vivo using DNA barcodes to determine how varying drug loadings affect their delivery behaviors in mice. A cost‐effective strategy is developed for simultaneously monitoring the biodistribution of a library of lipid nanoparticles (LNPs).
Letao Xu, Rui Chen, Xing Wang, Dawei Liu, Yun liu, Chun‐Xia Zhao   +5 more
wiley   +1 more source

Breaking boundaries: role of the brain barriers in metastatic process

Fluids and Barriers of the CNS
Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with ...
Nasim Izadi, Peter Solár, Klaudia Hašanová, Alemeh Zamani, Maryam Shahidian Akbar, Klára Mrázová, Martin Bartošík, Tomáš Kazda, Roman Hrstka, Marek Joukal   +9 more
doaj   +1 more source

The blood—brain barrier and the extracellular space of brain

, 1959
H. Davson, Eugene Spaziani
openalex   +1 more source

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. [PDF]

, 1979
Edward A. Neuwelt, Kenneth R. Maravilla, E. P. Frenkel, Samuel I. Rapaport, Suellen A. Hill, Peggy A. Barnett   +5 more
openalex   +1 more source

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, EarlyView.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

Overcoming the Blood–Brain Barrier: Successes and Challenges in Developing Nanoparticle-Mediated Drug Delivery Systems for the Treatment of Brain Tumours

International Journal of Nanomedicine, 2020
Chiara Ferraris,1 Roberta Cavalli,1 Pier Paolo Panciani,2 Luigi Battaglia1 1Department of Drug Science and Technology, University of Turin, Turin, Italy; 2Clinic of Neurosurgery, Spedali Civili and University of Brescia, Brescia, ItalyCorrespondence ...
Ferraris C, Cavalli R, Panciani PP, Battaglia L   +3 more
doaj  

Pathogenesis of AD is similar to that of uremic encephalopathy of Homocysteic acid. [PDF]

, 2011
Homocysteic acid (HA) has been established as a pathogen in Alzheimer's disease (AD) in 3xTg-AD model mice. However, it is not established whether HA is involved in the AD pathogenesis in humans.
Masayoshi Ichiba, Takeshi Tabira, Tohru Hasegawa   +2 more
core   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Development, maintenance and disruption of the blood-brain barrier

Nature Network Boston, 2013
B. Obermeier, R. Daneman, R. Ransohoff
semanticscholar   +1 more source