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Mannose Receptor C type 2 influences autoimmune neuroinflammation and blood-brain barrier integrity
Zierfuss B +31 more
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Astrocyte CB1receptors drive blood-brain barrier disruption in CNS inflammatory disease
Colomer T +14 more
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Experimental Eye Research, 1977
The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
William Oldendorf, William Oldendorf
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The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
William Oldendorf, William Oldendorf
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The Blood–Brain Barrier in Psychoneuroimmunology [PDF]
Immunology and Allergy Clinics of North America, 2006 The very term "psychoneuroimmunology" connotes separate compartments that interact. The BBB is the physical and physiologic dividing line between the immune system and the CNS and is the locale for interaction. Interactions between the immune system and the CNS are mediated at the BBB through a variety of mechanisms.
William A. Banks, William A. Banks
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Journal of Neuroimmune Pharmacology, 2013
The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Ingo Bechmann +3 more
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The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Ingo Bechmann +3 more
openaire +3 more sources
2016
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Richard M. Ransohoff +2 more
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In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Richard M. Ransohoff +2 more
openaire +3 more sources
2008
Publisher Summary Central nervous system (CNS) disorders are an important current and future priority for the pharmaceutical industry. In order for CNS drugs to penetrate to the brain tissue, they must pass through the blood–brain barrier (BBB). The BBB forms a permeation barrier that is more limiting to compound penetration than are most other ...
Edward H. Kerns, Li Di
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Publisher Summary Central nervous system (CNS) disorders are an important current and future priority for the pharmaceutical industry. In order for CNS drugs to penetrate to the brain tissue, they must pass through the blood–brain barrier (BBB). The BBB forms a permeation barrier that is more limiting to compound penetration than are most other ...
Edward H. Kerns, Li Di
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Pathophysiology of the blood-brain barrier
Springer Seminars in Immunopathology, 1996The blood-brain barrier (BBB) is a unique feature of the central nervous system (CNS), which isolates the brain from the external environment and prevents access of the majority of circulating substances in the blood to the brain. The concept of complete isolation of the brain from the rest of the body was coined at the beginning of the 20th century ...
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The Blood–Brain Barrier and Epilepsy
Epilepsia, 2006Summary: During the past several years, there has been increasing interest in the role of the blood–brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to image and study the human cerebrovasculature, and further developments in the research of metabolic deficiencies linked to seizure disorders (e.g., GLUT1 deficiency)
Damir Janigro +2 more
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