Results 131 to 140 of about 6,572,687 (353)

Review Paper: The Bed Incline and Prevention of Ventilator-Associated Pneumonia

Journal of Client-centered Nursing Care, 2016
Background: Ventilator-Associated Pneumonia (VAP) is the most common nosocomial (hospital acquired) infection among patients undergoing mechanical ventilation. It increases mortality rate, duration of mechanical intubated ventilation, and hospitalization
Tahereh Najafi Ghezeljeh, Leila Kalhor
doaj  

Zinc finger protein Y - linked as a potential biomarker for autoimmune hepatitis and multiple sclerosis which overlap with immune infiltration

Scientific Reports
Autoimmune Hepatitis (AIH) and Multiple Sclerosis (MS) are chronic inflammatory diseases with abnormal immune responses. This study aims to identify common biomarkers for AIH and MS using bioinformatics analysis.
Jian Liu, Di Guo, Meng Pu, Xin Li, Ying Xiao, Zi-wei Zhang, Yi-bin Tang, Yang Liu, Cun-gen Ma, Qing Wang   +9 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Circulation first – the time has come to question the sequencing of care in the ABCs of trauma; an American Association for the Surgery of Trauma multicenter trial [PDF]

, 2018
Background The traditional sequence of trauma care: Airway, Breathing, Circulation (ABC) has been practiced for many years. It became the standard of care despite the lack of scientific evidence.
AAST Multi-Institutional Trials Committee, Anto, Vincent, Callcut, Rachael A, Duane, Therese M., Dubose, Joseph, Enniss, Toby, Ferrada, Paula, Garcia, Alberto, Inaba, Kenji, Khor, Desmond, McNutt, Michelle, Moore, Forrest O., Nygaard, Rachel M., Phelan, Herb, Schreiber, Martin A., Skarupa, David J., Smith, Kira, Sperry, Jason, Tabas, Irene, Turay, David   +19 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

AS-IV-HP-β-CD molecular capsules alleviated motor dysfunction and DA neuronal loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation in MPTP-induced PD mice

Journal of Functional Foods
This study employed molecular simulation docking technology to identify the most suitable host molecules for encapsulating Astragaloside IV (AS-IV). AS-IV-HP-β-CD molecular capsules were prepared by encapsulating the hydrophobic groups of AS-IV in the ...
Lixia Yang, Haihua Huang, Yue Fan, Lei Xu, Xiaoming Jin, Baoguo Xiao, Cungen Ma, Huijie Fan, Zhi Chai   +8 more
doaj   +1 more source

Vasoconstrictors: a tale of two circulations [PDF]

, 2011
A cell can not survive without oxygen (O2) or nutrients. A single-celled organism can get both O2 and nutrients by simple diffusion. Since our body is built up of ~100 trillion (1014) cells, most of which never come into contact with outside air, we ...
Beer, V.J. (Vincent Jacob) de
core  

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis

Journal of Translational Medicine
Objective The present study aimed to investigate the potential role and molecular mechanism of procyanidin B2 (PCB2) in the treatment of multiple sclerosis (MS), with the hope of providing novel strategies for the precision treatment of MS.
Jian Liu, Meng Pu, Di Guo, Ying Xiao, Jin-zhu Yin, Dong Ma, Cun-gen Ma, Qing Wang   +7 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source