Results 91 to 100 of about 265,598 (321)

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

open access: yesAdvanced Therapeutics, EarlyView.
Antimicrobial resistance necessitates the development of new antibiotics with “resistance‐breaking” properties. In this study, conjugation of polycationic peptides is proven to represent a versatile strategy for the fast and affordable reactivation of daptomycin.
Sari Rasheed   +21 more
wiley   +1 more source

Integrating musculoskeletal ultrasound as a shared decision-making tool in hemophilia care: observations from a 3-year study

open access: yesResearch and Practice in Thrombosis and Haemostasis
Background: Hemophilia significantly impacts joint health, necessitating innovative strategies for early detection and management of joint damage. Objectives: This study assessed the impact of incorporating musculoskeletal ultrasound (MSKUS) into shared ...
Azusa Nagao   +3 more
doaj  

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

Mechanochemistry: Fundamental Principles and Applications

open access: yesAdvanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong   +4 more
wiley   +1 more source

Dynamical systems generated by a gonosomal evolution operator [PDF]

open access: yesarXiv, 2015
In this paper we consider discrete-time dynamical systems generated by gonosomal evolution operators of sex linked inheritance. Mainly we study dynamical systems of a hemophilia, which biologically is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a ...
arxiv  

Coagulation-Time of the Blood [PDF]

open access: green, 1904
FRED T. MURPHY, A. H. Gould
openalex   +1 more source

Association between intraoperative blood salvage and coagulation disorder after cardiopulmonary bypass

open access: yesJA Clinical Reports
Background This study investigated whether intraoperative blood salvage was associated with coagulation disorder diagnosed by conventional coagulation tests and thromboelastography (TEG) after cardiopulmonary bypass (CPB).
Masahiro Morinaga   +4 more
doaj   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

open access: yesAdvanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang   +17 more
wiley   +1 more source

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