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Blood Coagulation and Fibrinolysis
Angewandte Chemie International Edition in English, 1971AbstractAs a result of advances in protein chemistry it is now widely accepted that blood coagulation proceeds via a series of reaction steps of the nature of enzyme‐substrate reactions catalyzed by phospholipids. This also applies to the compensatory process of fibrinolysis.
Norbert Heimburger, Heiner Trobisch
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Biorheology, 1996
There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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Erythrocytes and Blood Coagulation [PDF]
Thrombosis and Haemostasis, 1974 SummaryThe action of intact and hemolyzed red cells in in vitro clotting systems is analyzed against the background of the clinical manifestations of red cell procoagulants in incompatible transfusions and hemolytic anemias in man and in experimental animals.
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The kinetics of blood coagulation
The Bulletin of Mathematical Biophysics, 1948The kinetics of the blood coagulation system have been formulated and an expression obtained for the “prothrombin time” in terms of the concentrations of the components of the system. A linear plot of data obtained from plasma dilution curves gives the values of the parameters of the system, and yields a mathematical method of comparing relative ...
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Prostacyclin and Blood Coagulation
Drugs, 1981Prostacyclin is a potent but unstable vasodilator, and inhibitor of platelet aggregation, which is produced by blood vessel walls. Platelet aggregability may be constantly conditioned in vivo by local or circulating prostacyclin. Prostacyclin is important in the maintenance of vascular homeostasis and may be implicated in certain disease states.
J. R. Vane, S. Moncada
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American Journal of Obstetrics and Gynecology, 1987
Blood coagulation consists of several interrelated reactions involving platelets and blood vessels, the classical cascade, and the fibrinolytic system. There is a complex of inhibiting influences on each of these schemes, and there are interrelationships among these inhibitory influences.
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Blood coagulation consists of several interrelated reactions involving platelets and blood vessels, the classical cascade, and the fibrinolytic system. There is a complex of inhibiting influences on each of these schemes, and there are interrelationships among these inhibitory influences.
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Journal of Biomedical Materials Research, 1968
AbstractThe effect of phenol and certain phenyl compounds on the different stages of the blood coagulation and fibrinolytic mechanism is investigated. Phenol has a complex action on blood coagulation. In an optimal concentration of 0.3% it produced a definite, though suboptimal platelet factor 3 activity, evolved factor XII, accelerated thrombin ...
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AbstractThe effect of phenol and certain phenyl compounds on the different stages of the blood coagulation and fibrinolytic mechanism is investigated. Phenol has a complex action on blood coagulation. In an optimal concentration of 0.3% it produced a definite, though suboptimal platelet factor 3 activity, evolved factor XII, accelerated thrombin ...
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Regulation of blood coagulation
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000The protein C anticoagulant pathway converts the coagulation signal generated by thrombin into an anticoagulant response through the activation of protein C by the thrombin-thrombomodulin (TM) complex. The activated protein C (APC) thus formed interacts with protein S to inactivate two critical coagulation cofactors, factors Va and VIIIa, thereby ...
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