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Blood Coagulation & Fibrinolysis, 2000
We have used three models to study the process of tissue factor-initiated blood coagulation. These are: synthetic 'plasma' mixtures prepared with the proteins and membranes involved in the reaction and its regulation; mathematical models based on the reaction kinetics, binding constants and stoichiometries of individual procoagulant and inhibitor ...
Butenas, S. +4 more
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We have used three models to study the process of tissue factor-initiated blood coagulation. These are: synthetic 'plasma' mixtures prepared with the proteins and membranes involved in the reaction and its regulation; mathematical models based on the reaction kinetics, binding constants and stoichiometries of individual procoagulant and inhibitor ...
Butenas, S. +4 more
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Blood Coagulation and Coagulation Tests
Medical Clinics of North America, 1984The hemostatic mechanism has evolved to provide efficient protection from traumatic blood loss and yet maintain the blood in a fluid state in the circulation as a whole. Recent advances in biochemistry have provided both detailed understanding of hemostasis and clinically useful coagulation assays to exploit this understanding.
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Blood Cells, Molecules, and Diseases, 2006
Our research aims to provide quantitatively transparent, biologically realistic descriptions of the processes involved in hemostasis which will permit predictions of the behavior of the coagulation system in normal and pathologic states. We use four models of coagulation: (1) numerical approximations of the tissue factor (Tf) pathway of thrombin ...
Kenneth G, Mann +3 more
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Our research aims to provide quantitatively transparent, biologically realistic descriptions of the processes involved in hemostasis which will permit predictions of the behavior of the coagulation system in normal and pathologic states. We use four models of coagulation: (1) numerical approximations of the tissue factor (Tf) pathway of thrombin ...
Kenneth G, Mann +3 more
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Blood Coagulation and Fibrinolysis
Angewandte Chemie International Edition in English, 1971AbstractAs a result of advances in protein chemistry it is now widely accepted that blood coagulation proceeds via a series of reaction steps of the nature of enzyme‐substrate reactions catalyzed by phospholipids. This also applies to the compensatory process of fibrinolysis.
N, Heimburger, H, Trobisch
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Biorheology, 1996
There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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Clinics in Laboratory Medicine, 1996
This article reviews the current understanding of coagulation and its role in overall hemostasis. Also provided is an overview of current screening and specialized tests of coagulation.
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This article reviews the current understanding of coagulation and its role in overall hemostasis. Also provided is an overview of current screening and specialized tests of coagulation.
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The Genetics of Blood Coagulation
1983Hemostasis is the term applied to the process that regulates the loss of blood from the circulatory system following injury. It involves three interrelated physiological mechanisms: constriction of blood vessels, aggregation of blood platelets to damaged subendothelial surfaces, and the formation of fibrin clots.
J B, Graham +3 more
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Journal of Biomedical Materials Research, 1968
AbstractThe effect of phenol and certain phenyl compounds on the different stages of the blood coagulation and fibrinolytic mechanism is investigated. Phenol has a complex action on blood coagulation. In an optimal concentration of 0.3% it produced a definite, though suboptimal platelet factor 3 activity, evolved factor XII, accelerated thrombin ...
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AbstractThe effect of phenol and certain phenyl compounds on the different stages of the blood coagulation and fibrinolytic mechanism is investigated. Phenol has a complex action on blood coagulation. In an optimal concentration of 0.3% it produced a definite, though suboptimal platelet factor 3 activity, evolved factor XII, accelerated thrombin ...
openaire +2 more sources