Results 31 to 40 of about 123,153 (305)

Impaired thrombin generation as a reproducible feature of bleeding disorder of unknown cause

Research and Practice in Thrombosis and Haemostasis
Background: Thrombin generation (TG) has previously been investigated in patients with bleeding disorder of unknown cause (BDUC) with discrepant results.
Tim Dreier, Dino Mehic, Justin Oosterlee, Helmut Haslacher, Cihan Ay, Ingrid Pabinger, Johanna Gebhart   +6 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Laboratory Evaluation Of Patients With Undiagnosed Bleeding Disorders

, 2016
The evaluation of patients with a bleeding tendency represents a challenge as the routinely available tests for evaluating bleeding disorders are limited, complicating the laboratory determination of the clinically observed bleeding tendency. As a result,
Santiago-Bassora, Fernanda Dutra, Paula, Erich Vinicius de, Annichino-Bizzacchi, Joyce M, Quaino, Susan Kelly Picoli, Orsi, Fernanda Andrade, Alves, Graziela Silveira Araújo, Montalvão, Silmara Aparecida Lima   +6 more
core   +2 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A rare disorder of blood coagulation

Modern pediatrics. Ukraine, 2022
The problem of impaired hemostasis remains relevant even today. Rare bleeding disorders that cause life-threatening bleeding in patient are often overlooked by clinicians. Rare blood coagulation disorders are a genetically determined group of coagulopathies caused by a deficiency of blood plasma proteins involved in hemostasis, as well as a deficiency ...
S.Yu. Romanenko, K.V. Vilchevska, I.O. Bakhchivandzhi, Yu.V. Martinenko   +3 more
openaire   +1 more source

Multiple cerebral infarctions in the context of malignancy [PDF]

, 2015
Coagulation disorders are common in patients with malignancy, sometimes leading to arterial and venous thrombosis. Such patients are therefore at increased risk for ischaemic stroke.
Paris, Etienne Mark
core  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Symmetrical peripheral gangrene complicating ventricular pseudoaneurysm: a report of an unusual case and a brief review of the literature [PDF]

Anais Brasileiros de Dermatologia, 2016
Symmetrical peripheral gangrene is an ischemic necrosis simultaneously involving the distal portions of two or more extremities without any proximal arterial obstruction or vasculitis.
Sudip Kumar Ghosh, Biswajit Majumder, Sandip Ghosh, Sharmistha Chatterjee, Megha Agarwal   +4 more
doaj   +2 more sources

Comparative frequency of Coagulation Factor II and Coagulation Factor V Alleles among new-born and senior citizens [PDF]

, 2005
Resistance to activated protein C is one of the most common inherited disorders associated with hereditary thrombophilia. A missense mutation in the gene coding for coagulation factor V (CF V Leiden) and which renders this procoagulant factor resistant ...
Bezzina Wettinger, Stephanie, Scerri, Christian A., Felice, Alex, Abela Medici, Joseph, Grochowska, Alicha   +4 more
core  

Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]

, 2010
Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Welsch, Ulrich, Peter Conzen, Bruegger, Dirk, Jacob, Matthias, Ingo Kaczmarek, Kaczmarek, Ingo, Conzen, Peter, Becker, Bernhard F., Stoeckelhuber, Mechthild, Rehm, Markus, Daniel Chappell, Dirk Bruegger, Chappell, Daniel, Bernhard F. Becker, Markus Rehm, Matthias Jacob, Ulrich Welsch, Mechthild Stoeckelhuber   +17 more
core   +1 more source