Results 191 to 200 of about 449,894 (358)

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature

Advanced Science, EarlyView.
A novel structure‐function relationship is identified for lung‐targeting ionizable lipids with nonpermanent charges. These lipids feature N‐methyl and secondary amine groups in their heads and three tails derived from epoxyalkanes, demonstrating superior pulmonary selectivity and efficiency.
Xiaoyan He, Runyuan Wang, Yan Cao, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, Jianfeng Li   +9 more
wiley   +1 more source

Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance

Advanced Science, EarlyView.
Inspired by the structure of sea sponges, a unique method involving microfluidic coaxial spinning and in situ polymerization is designed. Biomimetic tubular scaffolds ae fabricated. Composed of specific materials such as oxidized bacterial cellulose, bacterial cellulose and polydopamine, these scaffolds have excellent mechanical stability and ...
Si Meng, Nihuan Wu, Jie Fang, Yidan Yu, Xin Tang, Yihan Wang, Xiaokang Deng, Cheng Qi, Tiantian Kong, Tengda Ding, Zhou Liu   +10 more
wiley   +1 more source

Extracellular Matrix Targeted MRI Probes

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Gadolinium based MRI probes targeted to ECM components, either proteins or enzymes, hold promise for accurate molecular characterization and staging of fibrotic diseases in vivo. Non‐covalent binding probes (1), reactive probes (2), and enzyme‐responsive probes (3) are discussed.
Giuseppe Digilio, Sara Lacerda, Begoña Lavin Plaza, Alkystis Phinikaridou   +3 more
wiley   +1 more source

“Antenna Effect”‐Enhanced AuNPs@rGO Photothermal Coating Promotes 3D Printing of Osteogenic Active Scaffolds to Repair Bone Defects after Malignant Tumor Surgery

Advanced Science, EarlyView.
The T‐rGO@Au scaffold incorporates an rGO@AuNP composite photothermal coating inspired by the “antenna effect.” Under near‐infrared light irradiation, the scaffold induces the generation of reactive oxygen species (ROS) and localized thermal stimulation, leading to the effective elimination of tumor cells.
Xinyu Xu, Hao Wang, Xiaohan Mei, Dapeng Zeng, Zehao Yu, Shibo Liu, Ruiyan Li, Yanguo Qin   +7 more
wiley   +1 more source

Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations. [PDF]

Mol Biol Evol, 2014
Rallapalli PM, Orengo CA, Studer RA, Perkins SJ.   +3 more
europepmc   +1 more source

Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. [PDF]

, 1994
Vivien C. Yee, Lars C. Pedersen, I. Le Trong, P.D. Bishop, Ronald E. Stenkamp, D.C. Teller   +5 more
openalex   +1 more source

Morphology Effect of Puffball Spores on Hemostasis: A Promising Solution for Hemostatic Challenges

Advanced Science, EarlyView.
This work presents an innovative approach to address current challenges in hemostasis by drawing inspiration from the natural hemostatic material, Puffball spores (Bovistella sp.). Their unique hollow ball‐rod morphology and texture composition enable blood concentration and promote the release of procoagulant factors, while the nano‐protrusions on the
Xuechang Pei, Yue Feng, Yanru Wu, Jie Zhang, Jianlan Li, Shutai Jiang, Huijun Huang, Ping Qin, Guoqing Li, Xinrui Guo, Mingxian Liu, Chuanxi Wang, Hao Gao   +12 more
wiley   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor. [PDF]

, 1990
Doris I. Repke, Cynthia H. Gemmell, Anirban Guha, Vincent T. Turitto, George Broze, Yale Nemerson   +5 more
openalex   +1 more source