Results 191 to 200 of about 340,254 (355)

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. [PDF]

World J Biol Chem
Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M.   +3 more
europepmc   +1 more source

Thromboelastography variables, immune markers, and endothelial factors associated with shock and NPMODS in children with severe sepsis [PDF]

, 2019
Ignell, Steven P, Lin, John C, Saini, Arun, Spinella, Philip C   +3 more
core   +1 more source

Staphylococcal Superantigen-like Protein 10 (SSL10) Inhibits Blood Coagulation by Binding to Prothrombin and Factor Xa via Their γ-Carboxyglutamic Acid (Gla) Domain [PDF]

, 2013
Saotomo Itoh, Ryosuke Yokoyama, Go Kamoshida, Toshinobu Fujiwara, Hiromi Okada, Takemasa Takii, Tsutomu Tsuji, Satoshi Fujii, Hideki Hashizume, Kikuo Onozaki   +9 more
openalex   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Classic Coagulation Traits Vary According to Rh(D) (But Not ABO) Blood Groups. [PDF]

Hematol Rep
Morais-Junior GS, da Silva PD, da Silva MB, Reis de Oliveira J, Daros AC, Gomes CM, Nóbrega OT.   +6 more
europepmc   +1 more source

Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations. [PDF]

Mol Biol Evol, 2014
Rallapalli PM, Orengo CA, Studer RA, Perkins SJ.   +3 more
europepmc   +1 more source

Functional characterization of human blood coagulation factor XIa using hybridoma antibodies.

, 1985
D Sinha, A Koshy, F S Seaman, P N Walsh
openalex   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Research Progress on the Relationship Between Serum Uric Acid Levels and Coagulation Dysfunction in Preeclampsia. [PDF]

Int J Womens Health
Zou M, Tang D, Liu F, Guan F.
europepmc   +1 more source