Results 101 to 110 of about 2,362,330 (266)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study

Virulence
Klebsiella pneumoniae is a common causative pathogen of intra-abdominal infection with concomitant bacteraemia, leading to a significant mortality risk. The time to positivity (TTP) of blood culture is postulated to be a prognostic factor in bacteraemia ...
Yong-Ye Yang, I-Ting Tsai, Chung-Hsu Lai, Chih-Ping Chen, Chia‐Chi Chen, Yin-Chou Hsu   +5 more
doaj   +1 more source

Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia [PDF]

, 2018
Materials and methods: In a pilot study, results of real-time broad-range (16S rRNA) polymerase chain reaction (PCR) performed on 45 blood samples of pediatric cancer patients with fever and neutropenia were compared with blood culture results.
Aebi, Christoph, Ammann, Roland, Kühne, Thomas, Nadal, David, Niggli, Felix, Zucol, Franziska   +5 more
core  

The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia. [PDF]

, 2017
BACKGROUND.: Antibiotic exposure and specimen volume are known to affect pathogen detection by culture. Here we assess their effects on bacterial pathogen detection by both culture and polymerase chain reaction (PCR) in children.
Adrian, Peter V, Ahmed, Dilruba, Baggett, Henry C, Brooks, W Abdullah, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Feikin, Daniel R, Gitahi, Caroline, Hammitt, Laura L, Higdon, Melissa M, Howie, Stephen RC, Kaewpan, Anek, Karani, Angela, Karron, Ruth A, Kotloff, Karen L, Levine, Orin S, Madhi, Shabir A, Mazumder, Razib, McLellan, Jessica, Moore, David P, Murdoch, David R, Mwananyanda, Lawrence, O'Brien, Katherine L, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Rhodes, Julia, Saifullah, Md, Scott, J Anthony G, Seidenberg, Phil, Sow, Samba O, Tamboura, Boubou, Thea, Donald M, Zeger, Scott L   +35 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Microbial Agents and Antimicrobial Resistance Patterns in Blood Cultures of Intensive Care Unit Patients: Pre- and Post-COVID-19 Pandemic Analysis

Gazi Medical Journal
Objective: This study aimed to identify the microbial agents isolated from blood cultures of intensive care unit (ICU) patients and their antibiotic resistance rates before and after the Coronavirus Disease 2019 (COVID-19) pandemic.
Berna Erdal, Bensu Baylan, Hülya Duran, Nuri Kiraz, Yavuz Uyar   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

From Shadows to Spotlight: Enhancing Bacterial DNA Detection in Blood Samples through Cutting-Edge Molecular Pre-Amplification

Antibiotics
One of the greatest challenges to the use of molecular methods for diagnostic purposes is the detection of target DNA that is present only in low concentrations.
Martin Reinicke, Sascha Daniel Braun, Celia Diezel, Oliver Lemuth, Ines Engelmann, Theresa Liebe, Ralf Ehricht   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development and evaluation of TUMS medium, a novel biphasic culture medium for isolation of Brucella spp. from patients [PDF]

Background and objectives: There are limitations in time and technique for isolation of Brucella from patients. We developed a new Brucella culture medium and evaluated its efficiency compared to BACTEC blood culture system and serology.
حجازی, محمد جواد, فتح اله زاده, بهرام, مالک نژاد, پرویز, پیری دوگاهه, هادی   +3 more
core