Results 111 to 120 of about 2,362,330 (266)

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of a new protocol for rapid identification of Streptococcus pneumoniae in blood cultures using the modified bile solubility test: Gram staining is still standing

Journal of Clinical Microbiology
This study aimed to evaluate a new protocol of the bile solubility test performed directly on the blood from positive blood culture bottles to identify Streptococcus pneumoniae rapidly.
Antoine Aupaix, Alexia Verroken, Hector Rodriguez-Villalobos   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of Diagnostic Methods in Hospitalized Patients With Brucellosis in Iran [PDF]

Diagnosis of brucellosis is based on clinical symptoms and positive laboratory results. Because specificity of the serology tests is not satisfactory and sensitivity of the culture is low, polymerase chain reaction (PCR) can be an alternative method in ...
امیرزرگر, علی اکبر, جعفری, سیروس, حاجيا, مسعود, حسیبی, مهرداد, مالک نژاد, پرویز, پیری دوگاهه, هادی   +5 more
core   +1 more source

LightCycler SeptiFast technology in patients with solid malignancies: clinical utility for rapid etiologic diagnosis of sepsis [PDF]

, 2011
We retrospectively evaluated 54 results of the SeptiFast test from patients with solid malignancy admitted to the ICU between June 2009 and August 2011.
Dubská Lenka, Jelínek Petr, Minarikova Dagmar, Tejkalová Renata, Valík Dalibor, Vyskočilová Martina   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Bacterial DNA detection in blood using PCR/ESI-MS in neonates with suspected early onset infection

Frontiers in Cellular and Infection Microbiology
ObjectiveThe study aimed to assess the relationship between clinical features, routine laboratory parameters, including conventional blood culture, and identification of microorganisms by a commercial system of Polymerase Chain Reaction coupled with ...
Ajay K. Sinha, Ajay K. Sinha, Anja Saso, Arikana Mufunde, Steven T. Kempley, Steven T. Kempley, Mark Wilks, Mark Wilks, Mike Millar, Mike Millar   +9 more
doaj   +1 more source

Diagnosis of brucellosis by use of BACTEC blood culture and confirmation by PCR [PDF]

Brucellosis is one of the most common zoonotic diseases in Iran. Growth of Brucella is slow and blood cultures of these bacteria are time-consuming via classical methods.
امیرزرگر, علی اکبر, جعفری, سیروس, فتح اله زاده, بهرام, مالک نژاد, پرویز, پیری دوگاهه, هادی   +4 more
core  

Veriviljelynäytteenotto : Kuvallinen ohje [PDF]

, 2016
Opinnäytetyö oli toiminnallinen opinnäytetyö, jonka toimeksiantajana toimi Satakunnan sairaanhoitopiirin liikelaitos SataDiag. Opinnäytetyön tavoitteena oli toimia aseptisesti oikein suoritetun veriviljelynäytteenoton ohjemateriaalina Satakunnan ...
Heikkilä, Kati, Heiskanen, Suvi
core