Results 31 to 40 of about 629,937 (377)

Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms [PDF]

, 2019
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts.
Heller, Paula Graciela, Marin Oyarzún, Cecilia Paola   +1 more
core   +1 more source

Platelet factors attenuate inflammation and rescue cognition in ageing

Nature, 2023
Platelet factors transfer the benefits of young blood to the ageing brain in mice through CXCR3, which mediates the cellular, molecular and cognitive benefits of systemic PF4 on the aged brain.
A. B. Schroer, P. Ventura, Juliana Sucharov, R. Misra, M. K. K. Chui, Gregor Bieri, A. Horowitz, Lucas K. Smith, Katriel Encabo, Imelda Tenggara, Julien Couthouis, J. Gross, J. Chan, A. Luke, Saul A. Villeda   +14 more
semanticscholar   +1 more source

Hemorheological Failure in the Pathology of Cardio-vascular Complications in Patients with Diabetic Foot Syndrome [PDF]

, 2016
The literature that includes the study of cardiovascular complications in patients with diabetic foot syndrome was analyzed. The topicality of this problem is caused by the steady growth of diabetes mellitus morbidity among people.
Кorobko, Е. (Еlina)
core   +2 more sources

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

Haematologica, 2017
Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy. We sequenced the DNA from cases with unexplained
Marjorie Poggi, Matthias Canault, Marie Favier, Ernest Turro, Paul Saultier, Dorsaf Ghalloussi, Veronique Baccini, Lea Vidal, Anna Mezzapesa, Nadjim Chelghoum, Badreddine Mohand-Oumoussa, Céline Falaise, Rémi Favier, Willem H. Ouwehand, Mathieu Fiore, Franck Peiretti, Pierre Emmanuel Morange, Noémie Saut, Denis Bernot, Andreas Greinacher, NIHR BioResource, Alan T. Nurden, Paquita Nurden, Kathleen Freson, David-Alexandre Trégouët, Hana Raslova, Marie-Christine Alessi   +26 more
doaj   +1 more source

Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion [PDF]

, 2002
BACKGROUND: GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide (Integrilin) alone or in combination with ...
Bertuglia, Silva, Giusti, Andrea
core   +2 more sources

Stability and utility of flow cytometric platelet activation tests: A modality to bridge the gap between diagnostic demand and supply

Platelets, 2022
Light transmission aggregometry (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs). The requirement of customized aggregometer, large blood volume, normal platelet count and processing within 4 hours of venipuncture for ...
Rutvi Gautam Dave, Tulasi Geevar, Gayathiri Kaduvetti Chellaiya, Joy John Mammen, Ramya Vijayan, Ashok Samuel, Mahasampath Gowri, Sukesh Chandran Nair   +7 more
doaj   +1 more source

Diagnostic high-throughput sequencing of 2,396 patients with bleeding, thrombotic and platelet disorders.

Blood, 2019
A targeted high-throughput sequencing (HTS) panel test for clinical diagnostics requires careful consideration of the inclusion of appropriate diagnostic-grade genes, the ability to detect multiple types of genomic variation with high levels of analytic ...
K. Downes, Karyn Megy, Daniel Duarte, Minka J. A. Vries, J. Gebhart, S. Hofer, O. Shamardina, Sri V. V. Deevi, J. Stephens, R. Mapeta, Salih Tuna, Namir Al Hasso, M. Besser, N. Cooper, L. Daugherty, Nicholas S. Gleadall, D. Greene, M. Haimel, H. Martin, S. Papadia, S. Revel-Vilk, S. Sivapalaratnam, E. Symington, W. Thomas, C. Thys, A. Tolios, C. Penkett, W. Ouwehand, S. Abbs, M. Laffan, E. Turro, Ilenia Simeoni, A. Mumford, Y. Henskens, I. Pabinger, K. Gomez, K. Freson   +36 more
semanticscholar   +1 more source

Simplifying the diagnosis of inherited platelet disorders? The new tools do not make it any easier.

Blood, 2019
The molecular causes of many inherited platelet disorders are being unraveled. Next-generation sequencing facilitates diagnosis in 30% to 50% of patients.
A. Greinacher, Julia J. M. Eekels
semanticscholar   +1 more source

Climacteric Lowers Plasma Levels of Platelet-Derived Microparticles: A Pilot Study in Pre-versus Postmenopausal Women [PDF]

, 2012
Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet-(PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma
Andreas Rank, Bal L, Berckmans RJ, Berckmans RJ, Bettina Toth, Biro E, Corada M, Cramer EM, Dratva J, Erhard Hiller, Faddy MJ, Flaumenhaft R, Gemmell CH, Giansante C, Gilbert GE, Horstman LL, Joop K, Katharina Nikolajek, Koga H, Kuriyama N, Li X, Miyazaki Y, Myers DD, Nagata Y, Nieuwland R, Nomura S, Rabe T, Ramacciotti E, Rank A, Rank A, Rectenwald JE, Rienk Nieuwland, Sabine Roesner, Sagripanti A, Simak J, Sims PJ, Stevens RF, Tan KT, Tarantino MD, Thiagarajan P, Toth B, Travlos GS, van der Zee PM, Warren BA   +43 more
core   +3 more sources

Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography

Platelets, 2018
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange   +5 more
doaj   +1 more source