Results 11 to 20 of about 180,554 (264)

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

open access: yesHaematologica, 2017
Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy. We sequenced the DNA from cases with unexplained
Marjorie Poggi   +26 more
doaj   +1 more source

Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography

open access: yesPlatelets, 2018
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot   +5 more
doaj   +1 more source

Sticky Platelet Syndrome in Patients with Uninduced Venous Thrombosis

open access: yesTurkish Journal of Hematology, 2013
OBJECTIVE: Sticky platelet syndrome (SPS) is a common autosomal dominant inherited platelet disorder. SPS is characterized by platelet hyperreactivity and is associated with arterial and venous thrombosis.
Emre Tekgündüz   +5 more
doaj   +1 more source

Stability and utility of flow cytometric platelet activation tests: A modality to bridge the gap between diagnostic demand and supply

open access: yesPlatelets, 2022
Light transmission aggregometry (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs). The requirement of customized aggregometer, large blood volume, normal platelet count and processing within 4 hours of venipuncture for ...
Rutvi Gautam Dave   +7 more
doaj   +1 more source

A novel likely pathogenic variant in the RUNX1 gene as the cause of congenital thrombocytopenia

open access: yesBalkan Journal of Medical Genetics, 2023
Heterozygous pathogenic and likely pathogenic sequence variants in the RUNX1 (Runt-related Transcription Factor 1) gene are a common genetic cause of decreased platelet count and/or platelet dysfunction and an increased risk of developing myelodysplasia ...
Despotović M   +6 more
doaj   +1 more source

Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia

open access: yesTzu Chi Medical Journal, 2022
Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj   +1 more source

FREQUENCY OF INHERITED PLATELE FUNCTION DISORDERS–ARMED FORCES INSTITUTE OF PATHOLOGY EXPERIENCE

open access: yesPakistan Armed Forces Medical Journal, 2020
Objective: To determine the frequency and clinical features of inherited platelet function disorders diagnosed at Armed Forces Institute of Pathology. Study Design: Cross sectional study.
Saira Irum   +5 more
doaj   +4 more sources

Physico-Biochemical comparative study for Thyroid disorder patients in Ramadi city [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2015
The study aims at determining the impact of thyroid disorders in some blood and biochemical changes to try determine changes in some of the functions of the body as a result of these disorders, whether physiological or biochemical.
Muthana M. Awad, Abbas A. Hamdi
doaj   +1 more source

Use of microfluidics to assess the platelet-based control of coagulation

open access: yesPlatelets, 2017
This paper provides an overview of the various types of microfluidic devices that are employed to study the complex processes of platelet activation and blood coagulation in whole blood under flow conditions. We elaborate on how these devices are used to
Magdolna Nagy   +2 more
doaj   +1 more source

Resolving the missing link between single platelet force and clot contractile force

open access: yesiScience, 2022
Summary: Blood clot contraction plays an important role in wound healing and hemostasis. Although clot contraction is known to be driven by platelets, how single platelet forces relate to the forces generated by macroscopic clots remains largely unknown.
Yueyi Sun   +4 more
doaj   +1 more source

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