Results 31 to 40 of about 180,554 (264)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Features of Morphometric Changes in Platelets and Red Blood Cells in Women with Various Forms of Hypertensive Disorders in the Third Trimester of Pregnancy

Acta Biomedica Scientifica, 2020
Background. Arterial hypertension during pregnancy is accompanied by pronounced changes in microcirculation and hemostasis in the system, the state of which is largely determined by the structural and functional properties of red blood cells and ...
R. I. Sadov, T. O. Baev, I. A. Panova, S. V. Nazarov, G. N. Kuzmenko   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Discovery of bioactive compounds in the Chinese herbal formula NaoShuanTong Capsule (NSTC) against hemorheological disorders

Biotechnology & Biotechnological Equipment, 2018
NaoShuanTong capsule (NSTC) has been commonly used to treat blood circulation disorders and neurological dysfunction against cerebral ischemia in China. In this study, using an acute blood stasis rat model, canonical correlation analysis between chemical
Hong Liu, Chao-feng Long, Yao-yao Peng, Wei-jian Zhang, Pei-bo Li, Yong-gang Wang, Wei Peng, Zhong Wu, Wei-wei Su, Hong-liang Yao   +9 more
doaj   +1 more source

Considerations on Blood Platelets: A Neuron’s Mirror for Mood Disorders?

Open Journal of Blood Diseases, 2012
This work aims to be a reflection concerning a remarkable similarity between platelet and neuron. Through a series of experimental tests which have affected the fatty acid composition of the membrane of platelets, it was possible to provide a contribution to the scientific literature, which had already reported strong similarities between platelet and ...
Cocchi, Massimo, Tonello, Lucio, Gabrielli, Fabio   +2 more
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Advances in Platelet-Dysfunction Diagnostic Technologies

Biomolecules
The crucial role of platelets in hemostasis and their broad implications under various physiological conditions underscore the importance of accurate platelet-function testing. Platelets are key to clotting blood and healing wounds.
Inkwon Yoon, Jong Hyeok Han, Hee-Jae Jeon   +2 more
doaj   +1 more source

Underlying mechanism and specific prevention of hemolysis-induced platelet activation

Platelets, 2017
Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be ...
Thomas Gremmel, Simone Fedrizzi, Günter Weigel, Beate Eichelberger, Simon Panzer   +4 more
doaj   +1 more source

Device-Induced Hemostatic Disorders in Mechanically Assisted Circulation

Clinical and Applied Thrombosis/Hemostasis, 2021
Mechanically assisted circulation (MAC) sustains the blood circulation in the body of a patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) or on ventricular assistance with a ventricular assist device (VAD) or on extracorporeal ...
Shigang Wang MD, Bartley P. Griffith MD, Zhongjun J. Wu PhD   +2 more
doaj   +1 more source