Results 301 to 310 of about 420,739 (331)

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Oscillating Magnetic Field Induced Bone Injury Repair by using Drug‐Free Micromotors

Advanced Science, EarlyView.
This work presents a payload‐free, minimally invasive approach for bone repair using magnetic hydrogel micromotors, which enhance bone regeneration via localized micromovement stimulation, achieving a twofold increase in new bone formation in vivo. Abstract Bone injury repair remains a significant clinical challenge due to the tissue's limited self ...
Jie Shen, Rui He, Jiajun He, Lipeng Liao, Yongcan Huang, Shaoxiong Min, Xiaoreng Feng, Bin Chen, Ben Wang   +8 more
wiley   +1 more source

Ferrocene‐Functionalized Black Phosphorus Nanoplatform Enables Targeted and Prolonged MRI Visualization of Atherosclerotic Plaques

Advanced Science, EarlyView.
Aminoferrocene is employed to modify black phosphorus, generating stable phosphorus radicals (FcP). The FcP is then functionalized with hyaluronic acid (HA) to produce the HA‐FcP radical complex, thereby developing a novel, highly efficient, sensitive, long‐lasting, and low‐heavy‐metal‐content radical contrast agent for targeted imaging of ...
Xiao Huang, Yuanyuan Zhao, Miao Zhou, Yukang Guo, Haiyun Wang, Yuanyuan Chen, Jian Peng   +6 more
wiley   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Regulating billions of blood platelets: glycans and beyond.

Blood, 2015
Grozovsky R, Giannini S, Falet H, Hoffmeister KM.   +3 more
europepmc   +1 more source

Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. [PDF]

JACC Basic Transl Sci
Baaten CCFMJ, Wollenhaupt J, Henning TM, Vondenhoff S, Schröer JR, Stamellou E, Saritas T, Kurt B, Boger L, Antwerpen A, Hermann J, Nagy M, Sternkopf M, Buhl EM, Raffetseder U, van der Meijden PEJ, Kuijpers MJE, Spronk HMH, Schunk SJ, Jankowski J, Fliser D, Speer T, Boor P, Kramann R, Kahles F, Floege J, Marx N, Noels H.   +27 more
europepmc   +1 more source

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Blood platelet biochemistry

Thrombosis Research, 2012
Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet activation and aggregation and the formation a haemostatic plug ...
Hendrik B. Feys, Katleen Broos, Simon F. De Meyer, Hans Deckmyn, Karen Vanhoorelbeke   +4 more
openaire   +3 more sources

Blood Platelets and Platelet Transfusions

Archives of Internal Medicine, 1961
The application of quantitative biological and biochemical methods to the study of the blood platelets has led to revolutionary developments in our understanding of these elusive structures. 1 Until recently platelets were often regarded as non-cellular in nature, although it has long been known that they are of cellular origin.
openaire   +3 more sources

Platelets and Blood Vessels

Journal of Cardiovascular Pharmacology, 1984
The intravascular adhesion and aggregation of platelets initiate hemostasis and arterial thrombosis. In vitro, platelet aggregation is induced by many different agents; which of these is responsible for aggregation in vivo is now under investigation.
openaire   +3 more sources

Blood platelet production and morphology

Thrombosis Research, 2012
Circulating platelets are highly specialized cells produced by megakaryocytes (Mks) that participate in hemostatic and inflammatory functions. Despite their critical role little is known about the molecular mechanisms involved in their production from megakaryocytes, or about the pathogenesis of platelet disorders.
Alessandra Balduini, Alessandra Balduini, Alessandro Malara   +2 more
openaire   +3 more sources