Results 51 to 60 of about 7,188,262 (255)

Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype

EMBO Molecular Medicine, 2023
Blood phenotypes are defined by the presence or absence of specific blood group antigens at the red blood cell (RBC) surface, due to genetic polymorphisms among individuals.
Bérengère Koehl, Cédric Vrignaud, Mahmoud Mikdar, Thankam S Nair, Lucy Yang, Seyve Landry, Guy Laiguillon, Claudine Giroux‐Lathuile, Sophie Anselme‐Martin, Hanane El Kenz, Olivier Hermine, Narla Mohandas, Jean Pierre Cartron, Yves Colin, Olivier Detante, Raphaël Marlu, Caroline Le Van Kim, Thomas E Carey, Slim Azouzi, Thierry Peyrard   +19 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

CASP3 gene expression and the role of caspase 3 in the pathogenesis of depressive disorders

BMC Psychiatry, 2023
Background The aim of our study was to evaluate the expression of the CASP3 gene at both mRNA and protein levels in patients with depressive disorders and to determine the impact of caspase 3 in the pathogenesis of depression; Methods A total of 290 ...
Katarzyna Bliźniewska-Kowalska, Piotr Gałecki, Janusz Szemraj, Kuan-Pin Su, Jane Pei-Chen Chang, Małgorzata Gałecka   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study

Scientific Reports
Although clinical examination still represents the gold standard for the differential diagnosis of prolonged disorders of consciousness (pDoC), the introduction of innovative markers is essential for diagnosis and prognosis, due to the problem of covert ...
L. Coppola, G. Smaldone, A. M. Grimaldi, A. Estraneo, A. Magliacano, A. Soddu, G. Ciccarelli, M. Salvatore, C. Cavaliere   +8 more
doaj   +1 more source

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

Metabolites, 2019
Most human proteins are glycosylated. Attachment of complex oligosaccharides to the polypeptide part of these proteins is an integral part of their structure and function and plays a central role in many complex disorders.
Karsten Suhre, Irena Trbojević-Akmačić, Ivo Ugrina, Dennis O. Mook-Kanamori, Tim Spector, Johannes Graumann, Gordan Lauc, Mario Falchi   +7 more
doaj   +1 more source

In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations

Molecular Genetics and Metabolism Reports, 2020
The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace the ...
Georgios C. Kaiafas, Dionysia Papagiannopoulou, Αndroulla N. Miliotou, Anastasia S. Tsingotjidou, Parthenopi C. Chalkidou, Aikaterini C. Tsika, Georgios A. Spyroulias, Asterios S. Tsiftsoglou, Lefkothea C. Papadopoulou   +8 more
doaj   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1-Year Recurrence in Autoimmune GFAP Astrocytopathy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Hong Q, Xiao Y, Wu Y, Huang Z, Liang W, Xiao L, Shu Y, Lu T, Chang Y, Qiu W, Wang Y.   +10 more
europepmc   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source