Results 61 to 70 of about 7,188,262 (255)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Serum Pepsinogen Level of Dairy Cows with Gastrointestinal Disorders

İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 2017
The incidence of abomasal mucosal diseases in dairy cows suffering from gastrointestinal disorders is becoming more frequent in modern intensive production. Clinical signs are often non-specific.
Ali HAJIMOHAMMADI, Mohammad Reza TABANDEH, Saeed NAZIFI, Maryam KHOSRAVANIAN   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]

, 2013
Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Molecular Pathology of Prion Diseases [PDF]

, 2004
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of invariably fatal neurodegenerative disorders. Uniquely, they may present as sporadic, inherited, or infectious forms, all of which involve conversion of the normal ...
Vassallo, Neville, Herms, Jochen, Kretzschmar, Hans A.   +2 more
core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

The malaria secretome: from algorithms to essential function in blood stage infection [PDF]

, 2008
The malaria agent <i>Plasmodium falciparum</i> is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte.
Kooij Taco, John Adams, Harrison Travis, uvik So Bhattacharjee, Andrew P. Waters, Andy Waters, Waters, A.P., Harrison, T., Travis Harrison, Balu, B., van Ooij Christiaan, Haldar Kasturi, Adamson, J., Liolios Konstantinos, Kooij, T.W.A., N Luisa Hiller, Konstantinos Liolios, Souvik Bhattacharjee, Chris J. Janse, Christiaan van Ooij, Haldar, K., Balu Bharath, Hiller N. Luisa, Christiaan van Ooij, N. Luisa Hiller, Janse, C.J., Pamela Tamez, Ramesar, J., Bharath Balu, Kasturi Haldar, Chris Janse, Waters Andy, Janse Chris, Tamez Pamela, van Ooij, C., Hiller, N.L., Chris J Janse, Jai Ramesar, Tamez, P., Bhattacharjee, S., Ramesar Jai, Liolios, K., Taco Kooij, Adams John, Bhattacharjee Souvik, Andrew P Waters   +45 more
core   +1 more source

CHEMICAL COMPOSITION OF BLOOD SERUM OF PIGS AT EXPERIMENTAL AND SPONTANEOUS CRYPTOSPORIDIOSIS

Российский паразитологический журнал, 2016
The issues of pathogenesis of cryptosporidiosis in pigs are studied. The cryptosporidiosis infection at experimental and spontaneous infection may lead to significant morphological changes in the pigs body: the number of leukocytes is increased ...
N. S. MALACHOV, V. A. VASILYEVA
doaj