Results 61 to 70 of about 1,236,436 (312)

CASP3 gene expression and the role of caspase 3 in the pathogenesis of depressive disorders

BMC Psychiatry, 2023
Background The aim of our study was to evaluate the expression of the CASP3 gene at both mRNA and protein levels in patients with depressive disorders and to determine the impact of caspase 3 in the pathogenesis of depression; Methods A total of 290 ...
Katarzyna Bliźniewska-Kowalska, Piotr Gałecki, Janusz Szemraj, Kuan-Pin Su, Jane Pei-Chen Chang, Małgorzata Gałecka   +5 more
doaj   +1 more source

Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]

, 2012
Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Anastasi, Anastasi, Andersen, Andersen, Bast, Bast, Drapkin, Drapkin, Duffy, Duffy, Escudero, Escudero, Galgano, Galgano, Heintz, Heintz, Hellstrom, Hellstrom, Hellstrom, Hellstrom, Holcomb, Holcomb, Huhtinen, Huhtinen, Jacob, Jacob, Jacobs, Jacobs, Kurman, Kurman, Liu, Liu, Montagnana, Montagnana, Moore, Moore, Nolen, Nolen, Tuxen, Tuxen   +39 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

Metabolites, 2019
Most human proteins are glycosylated. Attachment of complex oligosaccharides to the polypeptide part of these proteins is an integral part of their structure and function and plays a central role in many complex disorders.
Karsten Suhre, Irena Trbojević-Akmačić, Ivo Ugrina, Dennis O. Mook-Kanamori, Tim Spector, Johannes Graumann, Gordan Lauc, Mario Falchi   +7 more
doaj   +1 more source

In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations

Molecular Genetics and Metabolism Reports, 2020
The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace the ...
Georgios C. Kaiafas, Dionysia Papagiannopoulou, Αndroulla N. Miliotou, Anastasia S. Tsingotjidou, Parthenopi C. Chalkidou, Aikaterini C. Tsika, Georgios A. Spyroulias, Asterios S. Tsiftsoglou, Lefkothea C. Papadopoulou   +8 more
doaj   +1 more source

BIOCHEMICAL PATHWAYS OF METABOLIC DISORDERS IN PSORIASIS

Juvenis Scientia, 2021
The development of metabolic disorders occurs in psoriasis: insulin resistance, systemic inflammation, atherosclerosis, oxidative stress and obesity. The paper presents pathological biochemical pathways of metabolic disorders development which is caused ...
O. V. Samburskaya, S. Yu Kalinchenko, N. V. Batkaeva   +2 more
doaj   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome

Frontiers in Pharmacology, 2022
Radix Rehmanniae (RR, from Radix Rehmanniae (Gaertn.) DC.) is a natural medicine used in traditional Chinese medicine (TCM) since ancient times for the treatment of blood disorders. RR is steamed to get Rehmanniae Radix Praeparata (RP), which has a tonic
Wensen Zhang, Na Cui, Fazhi Su, Yangyang Wang, Bingyou Yang, Yanping Sun, Wei Guan, Haixue Kuang, Qiuhong Wang   +8 more
doaj   +1 more source

Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit. [PDF]

, 2011
Objective of the study was to test the efficacy, safety, and tolerability of two single doses of Epoetin alfa in patients with Friedreich's ataxia. Ten patients were treated subcutaneously with 600 IU/kg for the first dose, and 3 months later with 1200 ...
ACQUAVIVA, Fabio, ANTENORA, ANTONELLA, CARLOMAGNO, guido, CITTADINI, ANTONIO, COCOZZA, SERGIO, DE MICHELE, GIUSEPPE, Denaro A., FILLA, ALESSANDRO, GUACCI, ANNA, Marsili A., Perrotta G., PIRO, RAFFAELE, Puorro G., SACCA', FRANCESCO   +13 more
core   +1 more source