Results 61 to 70 of about 824,157 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CHEMICAL COMPOSITION OF BLOOD SERUM OF PIGS AT EXPERIMENTAL AND SPONTANEOUS CRYPTOSPORIDIOSIS

Российский паразитологический журнал, 2016
The issues of pathogenesis of cryptosporidiosis in pigs are studied. The cryptosporidiosis infection at experimental and spontaneous infection may lead to significant morphological changes in the pigs body: the number of leukocytes is increased ...
N. S. MALACHOV, V. A. VASILYEVA
doaj  

Novel loss-of-function mutations in VPS13A cause chorea-acanthocytosis in two families

Frontiers in Neurology
IntroductionChorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis (NA) caused by mutations in VPS13A (vacuole protein sorting-associated protein 13A). ChAc is characterized by the presence of spherocytes and neurological symptoms.
Xiao-Hong Lin, Bin Xiao, Ru-Kai Chen, Jia-Ying Chen, Nai-Qing Cai, Chun-Yan Cao, Li-Qiong Zhan   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

SOME FEATURES OF CURATIVE ACTION OF A MILK THISTLE OIL REALIZATION FOR LEVER TOXICAL DAMAGE WITH FORMALINE

Фармация и фармакология (Пятигорск), 2015
The article represents the results of experimental researches of metabolic disorders provoked by subacute formalin injection to rats and study of possibility for correction of received changes by the saint milk thistle oil by the changes of clinical and ...
V. V. Kozlova, D. A. Konovalov, N. N. Vdovenko-Martynova, I. V. Pshukova, A. A. Kruglaya   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The peculiarities of the metabolism processes in patients with the exacerbation of extensive psoriasis [PDF]

Саратовский научно-медицинский журнал, 2011
Purpose. The study of some indices of the metabolism in patients with the exacerbation of extensive psoriasis, the investigation of the revealed disorder dependence on the clinical peculiarities of the disease and anamnesis data. Methods.
Baityakov V. V.
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation

Medicine Science
The Coronavirus Disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), highlighted significant gaps in our understanding of the virus's molecular structure, its biological properties, and the ...
Onur Ozturk, Evren Kilinc, Batuhan Gorkem Irez, Emel Timucin   +3 more
doaj   +1 more source

The Potential Role of Cell Penetrating Peptides in the Intracellular Delivery of Proteins for Therapy of Erythroid Related Disorders

Pharmaceuticals, 2013
The erythroid related disorders (ERDs) represent a large group of hematological diseases, which in most cases are attributed either to the deficiency or malfunction of biosynthetic enzymes or oxygen transport proteins.
Lefkothea C. Papadopoulou, Asterios S. Tsiftsoglou   +1 more
doaj   +1 more source