Results 81 to 90 of about 833,559 (317)

Novel loss-of-function mutations in VPS13A cause chorea-acanthocytosis in two families

Frontiers in Neurology
IntroductionChorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis (NA) caused by mutations in VPS13A (vacuole protein sorting-associated protein 13A). ChAc is characterized by the presence of spherocytes and neurological symptoms.
Xiao-Hong Lin, Bin Xiao, Ru-Kai Chen, Jia-Ying Chen, Nai-Qing Cai, Chun-Yan Cao, Li-Qiong Zhan   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens [PDF]

, 2006
PURPOSE. To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken.METHODS. Linkage analysis, with previously uncharacterized microsatellite markers from chicken chromosome
Hocking, Paul M., Tummala, Hemanth, Getty, Paul, Ali, Manir, Burt, David W., Inglehearn, Chris F., Lester, Douglas H.   +6 more
core   +1 more source

The Potential Role of Cell Penetrating Peptides in the Intracellular Delivery of Proteins for Therapy of Erythroid Related Disorders

Pharmaceuticals, 2013
The erythroid related disorders (ERDs) represent a large group of hematological diseases, which in most cases are attributed either to the deficiency or malfunction of biosynthetic enzymes or oxygen transport proteins.
Lefkothea C. Papadopoulou, Asterios S. Tsiftsoglou   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The molecular pathogenesis of myeloproliferative neoplasms

, 2010
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage.
Jones, Amy Victoria
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. [PDF]

, 2008
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension ...
Muttukrishna Shanthi, Muttukrishna, S, Khalil Asma, Khalil, A, Jauniaux, E, Harrington, K, Jauniaux Eric, Kevin Harrington, Harrington Kevin, Shanthi Muttukrishna, Asma Khalil, Eric Jauniaux   +11 more
core   +1 more source

Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation

Medicine Science
The Coronavirus Disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), highlighted significant gaps in our understanding of the virus's molecular structure, its biological properties, and the ...
Onur Ozturk, Evren Kilinc, Batuhan Gorkem Irez, Emel Timucin   +3 more
doaj   +1 more source

The peculiarities of the metabolism processes in patients with the exacerbation of extensive psoriasis [PDF]

Саратовский научно-медицинский журнал, 2011
Purpose. The study of some indices of the metabolism in patients with the exacerbation of extensive psoriasis, the investigation of the revealed disorder dependence on the clinical peculiarities of the disease and anamnesis data. Methods.
Baityakov V. V.
doaj