Results 81 to 90 of about 1,236,436 (312)

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

CHEMICAL COMPOSITION OF BLOOD SERUM OF PIGS AT EXPERIMENTAL AND SPONTANEOUS CRYPTOSPORIDIOSIS

Российский паразитологический журнал, 2016
The issues of pathogenesis of cryptosporidiosis in pigs are studied. The cryptosporidiosis infection at experimental and spontaneous infection may lead to significant morphological changes in the pigs body: the number of leukocytes is increased ...
N. S. MALACHOV, V. A. VASILYEVA
doaj  

Novel loss-of-function mutations in VPS13A cause chorea-acanthocytosis in two families

Frontiers in Neurology
IntroductionChorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis (NA) caused by mutations in VPS13A (vacuole protein sorting-associated protein 13A). ChAc is characterized by the presence of spherocytes and neurological symptoms.
Xiao-Hong Lin, Bin Xiao, Ru-Kai Chen, Jia-Ying Chen, Nai-Qing Cai, Chun-Yan Cao, Li-Qiong Zhan   +6 more
doaj   +1 more source

The Potential Role of Cell Penetrating Peptides in the Intracellular Delivery of Proteins for Therapy of Erythroid Related Disorders

Pharmaceuticals, 2013
The erythroid related disorders (ERDs) represent a large group of hematological diseases, which in most cases are attributed either to the deficiency or malfunction of biosynthetic enzymes or oxygen transport proteins.
Lefkothea C. Papadopoulou, Asterios S. Tsiftsoglou   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

SOME FEATURES OF CURATIVE ACTION OF A MILK THISTLE OIL REALIZATION FOR LEVER TOXICAL DAMAGE WITH FORMALINE

Фармация и фармакология (Пятигорск), 2015
The article represents the results of experimental researches of metabolic disorders provoked by subacute formalin injection to rats and study of possibility for correction of received changes by the saint milk thistle oil by the changes of clinical and ...
V. V. Kozlova, D. A. Konovalov, N. N. Vdovenko-Martynova, I. V. Pshukova, A. A. Kruglaya   +4 more
doaj   +1 more source

The Evidence Behind the Diagnostic Investigation of Canine Idiopathic Epilepsy [PDF]

, 2016
Clinical bottom lineThere remains until recently an overall lack of clarity for the practical criteria for the diagnosis of canine idiopathic epilepsy.
Brodbelt, D C, Charalambous, M, Volk, H A   +2 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source