Results 71 to 80 of about 7,188,262 (255)
Novel loss-of-function mutations in VPS13A cause chorea-acanthocytosis in two families
Frontiers in NeurologyIntroductionChorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis (NA) caused by mutations in VPS13A (vacuole protein sorting-associated protein 13A). ChAc is characterized by the presence of spherocytes and neurological symptoms.
Xiao-Hong Lin +6 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Фармация и фармакология (Пятигорск), 2015 The article represents the results of experimental researches of metabolic disorders provoked by subacute formalin injection to rats and study of possibility for correction of received changes by the saint milk thistle oil by the changes of clinical and ...
V. V. Kozlova +4 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Medicine ScienceThe Coronavirus Disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), highlighted significant gaps in our understanding of the virus's molecular structure, its biological properties, and the ...
Onur Ozturk +3 more
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The peculiarities of the metabolism processes in patients with the exacerbation of extensive psoriasis [PDF]
Саратовский научно-медицинский журнал, 2011 Purpose. The study of some indices of the metabolism in patients with the exacerbation of extensive psoriasis, the investigation of the revealed disorder dependence on the clinical peculiarities of the disease and anamnesis data. Methods.
Baityakov V. V.
doaj
Pharmaceuticals, 2013 The erythroid related disorders (ERDs) represent a large group of hematological diseases, which in most cases are attributed either to the deficiency or malfunction of biosynthetic enzymes or oxygen transport proteins.
Lefkothea C. Papadopoulou +1 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Recombinant factorVIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A [PDF]
, 2015 This work was supported by funding from Biogen, including funding for the editorial and writing support in the the development of this ...
Barnes, C +11 more
core +1 more source