Results 91 to 100 of about 324,423 (310)

Rheological investigation of manufacturability and injectability of highly concentrated monoclonal antibody formulations [PDF]

open access: yes, 2014
Highly concentrated protein therapeutics offer a convenient way for subcutaneous (sc) drug administration by the patient him-/herself or a healthcare professional. As the therapy e.g.
Allmendinger, Andrea Martina
core   +1 more source

An update on medium- and low-abundant blood plasma proteome of horse

open access: yesAnimal, 2018
The main objectives of the study were to: (1) deeply analyse the serum protein composition of Equus caballus, (2) assess the effectiveness of the high-abundant protein depletion and improve the concentration of medium- and low-abundant proteins.
A. Lepczyński   +6 more
doaj   +1 more source

Estimation and isolation of ceruloplasmin and some biochemical indicators in diabetes mellitus type II patients compared to healthy controls in Kirkuk Province, Iraq

open access: yesMedical Journal of Babylon, 2020
Background: The pathogenesis of diabetes mellitus (DM) was affected by oxidative stress. Many inflammatory markers having antioxidant property, among them ceruloplasmin (CP), which is the appropriate candidate to recognize the general insulin resistance ...
Karam Yahya Noah   +2 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

open access: yesAdvanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu   +7 more
wiley   +1 more source

GENETIC VARIATION IN THREE BREEDS OF INDONESIAN LOCAL DUCKS BASED ON BLOOD AND EGG WHITE PROTEIN POLYMORPHISM [PDF]

open access: yesJournal of the Indonesian Tropical Animal Agriculture, 2013
A study of genetic variation of four blood protein loci and three egg white loci in three breeds of Indonesian local ducks (Magelang duck = MAD, Tegal duck = TED and Mojosari duck= MOD) was investigated by using polyacrilamide gel electrophoresis (PAGE).
S. Johari, S. Ekasari, E. Kurnianto
doaj  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

open access: yesAdvanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu   +12 more
wiley   +1 more source

Genetic analysis of protein composition of bovine milk [PDF]

open access: yes, 2010
This thesis is part of the Dutch Milk Genomics Initiative, and the general aim was to obtain more insight into the genetic background of bovine milk protein composition.
Schopen, G.C.B.
core  

Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells [PDF]

open access: yes, 2010
Human skeletal stem cells (STRO-1 positive/STRO-1+) respond to different topographical features in various ways. On a flat surface these cells spread and tend to develop a fibroblast-like morphology.
Burgess, K.E.V.   +15 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia   +17 more
wiley   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

open access: yes, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter   +3 more
core  

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