Results 111 to 120 of about 11,399,320 (390)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Identification of tuberculosis-associated proteins in whole blood supernatant

BMC Infectious Diseases, 2011
Background Biological parameters are useful tools for understanding and monitoring complicated disease processes. In this study, we attempted to identify proteins associated with active pulmonary tuberculosis (TB) using a proteomic approach.
Lien Luu, Le Hang Nguyen, Kobayashi Nobuyuki, Kaburagi Yasushi, Hirano Hisashi, Yasuda Kazuki, Takahashi Eri, Kano Keiko, Sakurada Shinsaku, Tanaka Takahiro, Matsushita Ikumi, Hijikata Minako, Uchida Takafumi, Keicho Naoto   +13 more
doaj   +1 more source

PUEPro : A Computational Pipeline for Prediction of Urine Excretory Proteins [PDF]

, 2016
This work is supported by the National Natural Science Foundation of China (Grant Nos. 81320108025, 61402194, 61572227), Development Project of Jilin Province of China (20140101180JC) and China Postdoctoral Science Foundation (2014T70291 ...
Chen, Xin, Du, Wei, Liang, Yanchun, Pang, Wei, Wang, Yan, Xu, Ying, Zhang, Chi   +6 more
core   +1 more source

Stability of Proteins in Dried Blood Spot Biobanks

Molecular & Cellular Proteomics, 2017
An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples
Johan Björkesten, Stefan Enroth, Q. Shen, Lotta Wik, D. Hougaard, A. Cohen, Lene Sörensen, V. Giedraitis, M. Ingelsson, A. Larsson, M. Kamali-Moghaddam, U. Landegren   +11 more
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Timing and modality of the sclerosing agents binding to the human proteins: laboratory analysis and clinical evidences

Veins and Lymphatics, 2014
Sclerosing agents (SA) are blood inactivated. Nevertheless, investigations concerning the interaction among SA and blood components have never been deeply investigated.
Lorenzo Tessari, Marcello Izzo, Attilio Cavezzi, Francesco Zini, Mirko Tessari, Mario Ambrosino, Roberto Fanelli   +6 more
doaj   +1 more source

Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]

, 2018
This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan, Collie-Duguid, Elaina S. R., De Paiva Alves, Eduardo, El-Omar, Emad, Gibson, Sophie, Goddard, Mark, Hansen, Richard, Hold, Georgina L., Karcher, Anne Marie, MacLaren, Andrew, Munro, Mike   +10 more
core   +4 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Interactions between DMPC liposomes and the serum blood proteins HSA and IgG.

Journal of Physical Chemistry B, 2009
The interaction between two serum blood proteins, namely human serum albumin (HSA) and human immunoglobulin G (IgG), with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) liposomes has been studied in detail using dynamic light scattering, flow ...
J. Sabín, G. Prieto, J. Ruso, P. Messina, F. Salgado, M. Nogueira, M. Costas, F. Sarmiento   +7 more
semanticscholar   +1 more source