Results 111 to 120 of about 11,143,550 (369)
Analytical and Bioanalytical Chemistry, 2018 The analysis of aggregates of therapeutic proteins is crucial in order to ensure efficacy and patient safety. Typically, the analysis is performed in the finished formulation to ensure that aggregates are not present.
M. Leeman +4 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients
BiomedicinesBackground: Glioblastoma multiforme (GBM) is a very malignant brain tumor. GBM exhibits cellular and molecular heterogeneity that can be exploited to improve patient outcomes by individually tailoring chemotherapy regimens.
Alexander N. Chernov +10 more
doaj +1 more source
GLA PROTEINS – THE WARNING SIGN FOR THE BLOOD VESSELS [PDF]
Journal of IMAB, 2019 The aim of the present work was to perform a critical analysis of the literature related to the role of the extrahepatic matrix Gla-protein (MGP) as an inhibitor of vascular calcification. Online databases PubMed, Google Scholar, Scopus, Science Direct,
Yulian S. Snegarov, Bistra T. Galunska
doaj +1 more source
High contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed Multispectral Optoacoustic Tomography (tuMSOT) [PDF]
, 2014 Photocontrol of reversibly switchable fluorescent proteins (RSFPs) was used to program optoacoustic signal time courses that were temporally unmixed to increase the proteins contrast-to-noise-ratios (CNRs) in optoacoustic imaging. In this way, two variants of the RSFP Dronpa with very similar optoacoustic spectra could be readily discriminated in the ...
arxiv +1 more source
Molecular origin of blood-based infrared fingerprints [PDF]
arXiv, 2021 Previous studies demonstrated that infrared absorption spectra of blood sera may help disease detection. For clinical translation of this approach, it is important to determine the molecular origin of disease-related spectral perturbations. To that end, we supplemented infrared spectroscopy with biochemical fractionation and proteomic profiling, which ...
arxiv
Contribution of the sympathetic nervous system to the pathogenesis of salt-sensitive hypertension [PDF]
, 2016 Dysregulation of the sodium-chloride cotransporter (NCC) is believed to significantly impact blood pressure. Recent studies have implicated overactivity of the sympathetic nervous system as a mechanism driving renal NCC dysregulation to evoke the ...
Pazzol, Michael Lee
core +1 more source
Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome [PDF]
, 2016 The phosphorylation status of red blood cell proteins is strongly altered during the infection by the malaria parasite Plasmodium falciparum. We identify the key phosphorylation events that occur in the erythrocyte membrane and cytoskeleton during ...
Bouyer, Guillaume +7 more
core +4 more sources
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2012 Se presentan los resultados de la estandarización de las técnicas de electroforesis de hemoglobina (Hb), isoenzimas de la deshidrogenasa láctica (LDH) y proteinuria en el equipo Hydrasys 2, así como el estudio de pacientes atendidos en el Instituto de ...
Liz Mabel Díaz-Barroso +6 more
doaj