Results 111 to 120 of about 2,314,484 (362)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus

Scientific Reports
Macrovascular complications are leading causes of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), yet early diagnosis of cardiovascular disease (CVD) in this population remains clinically challenging.
Ningjie Zhang, Yan Wang, Hui Zhang, Huilong Fang, Xinyi Li, Zhifen Li, Zhenghang Huan, Zugui Zhang, Yongjun Wang, Wei Li, Zheng Gong   +10 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Effect of Hydroalcoholic Extract of Artemisia dracunculus L. (Tarragon) on the Levels of Serum Proteins in Small Laboratory Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Tarragon (Artemisia dracunculus L.) is a plant, which has nutritional and therapeutic uses for years. In traditional medicine, this plant has been used for relief of indigestion, detoxification of the body, treatment of ...
Mehrdad Modaresi, Mahboobeh Madani, Mahnaz Alasvand Zarasvand   +2 more
doaj  

Identification of salivary gland proteins depleted after blood feeding in the malaria vector Anopheles campestris-like mosquitoes (Diptera: Culicidae).

PLoS ONE, 2014
Malaria sporozoites must invade the salivary glands of mosquitoes for maturation before transmission to vertebrate hosts. The duration of the sporogonic cycle within the mosquitoes ranges from 10 to 21 days depending on the parasite species and ...
Sriwatapron Sor-suwan, Narissara Jariyapan, Sittiruk Roytrakul, Atchara Paemanee, Atchara Phumee, Benjarat Phattanawiboon, Nuchpicha Intakhan, Wetpisit Chanmol, Paul A Bates, Atiporn Saeung, Wej Choochote   +10 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Retracted: Machine Learning of ZnO Interaction with Immunoglobulins and Blood Proteins in Medicine. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Characterization of VspB of Borrelia turicatae , a Major Outer Membrane Protein Expressed in Blood and Tissues of Mice [PDF]

, 1999
Pamela M. Pennington, Diego Cadavid, Alan G. Barbour   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Measurement of Non-Enzymatic Glycosylated Serum Proteins (GSP) by Improved Thiobarbitoric Acid Assay

پزشکی بالینی ابن سینا, 1999
Several classes of protein may undergo non-enzymetic addition of glucose derived product. Hemoglobin was the first protein shown to be modified. Subsequent studies have demonstrated a similar effect of glucose on lens crystalline, collagen, erythrocyte ...
Iraj Khodadadi, Mahin Zahraei
doaj