Measurement of Non-Enzymatic Glycosylated Serum Proteins (GSP) by Improved Thiobarbitoric Acid Assay
پزشکی بالینی ابن سینا, 1999 Several classes of protein may undergo non-enzymetic addition of glucose derived product. Hemoglobin was the first protein shown to be modified. Subsequent studies have demonstrated a similar effect of glucose on lens crystalline, collagen, erythrocyte ...
Iraj Khodadadi, Mahin Zahraei
doaj
Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets
Biochemistry Research International, 2016 Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The aim of present work was studying of the primary effects of silica nanoparticles (SiNPs) on haemostasis in vitro.
Volodymyr Gryshchuk, Natalya Galagan
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Alterations in blood proteins in the prodromal stage of bipolar II disorders. [PDF]
Sci Rep, 2022 Lee H +18 more
europepmc +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Kinetics-like equation for cerebrospinal fluid-blood diffusion models
Revista Cubana de Investigaciones Biomédicas, 2020 Introduction: The diffusion of proteins from the blood to the cerebrospinal fluid is influenced by its molecular weight and by the intrinsic properties and biological properties of the protein. Objective: Determinate the diffusion of new proteins as they
José Alejandro Rodríguez-Pérez +6 more
doaj
A genetic correlation scan identifies blood proteins associated with bone mineral density. [PDF]
BMC Musculoskelet Disord, 2022 Xu J +8 more
europepmc +1 more source
ReactEmbed: A Cross-Domain Framework for Protein-Molecule Representation Learning via Biochemical Reaction Networks [PDF]
arXivThe challenge in computational biology and drug discovery lies in creating comprehensive representations of proteins and molecules that capture their intrinsic properties and interactions. Traditional methods often focus on unimodal data, such as protein sequences or molecular structures, limiting their ability to capture complex biochemical ...
arxiv
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Effect of Time to Detection on the Measured Concentrations of Blood Proteins Associated with Alzheimer's Disease. [PDF]
Dement Geriatr Cogn Dis Extra, 2022 Chen HH +5 more
europepmc +1 more source