Results 131 to 140 of about 11,143,550 (369)

Stability of Proteins in Dried Blood Spot Biobanks

Molecular & Cellular Proteomics, 2017
An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples
Johan Björkesten, Stefan Enroth, Q. Shen, Lotta Wik, D. Hougaard, A. Cohen, Lene Sörensen, V. Giedraitis, M. Ingelsson, A. Larsson, M. Kamali-Moghaddam, U. Landegren   +11 more
semanticscholar   +1 more source

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

Engineering blood cells and proteins as blood substitutes: A short review [PDF]

Biotechnology and Bioprocess Engineering, 2007
In this brief review, basic principles and recent progresses on the development of therapeutic substitutes for major blood components are briefly discussed with primary focus on the red cell substitutes.
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Red Blood Cells: Chasing Interactions

Frontiers in Physiology, 2019
Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and most intracellular machineries during their maturation process.
Virginia Pretini, Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk   +8 more
doaj   +1 more source

The plasma protein fibrinogen stabilizes clusters of red blood cells in microcapillary flows [PDF]

arXiv, 2014
The supply of oxygen and nutrients and the disposal of metabolic waste in the organs depend strongly on how blood, especially red blood cells, flow through the microvascular network. Macromolecular plasma proteins such as fibrinogen cause red blood cells to form large aggregates, called rouleaux, which are usually assumed to be disaggregated in the ...
arxiv  

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

Scientific Reports, 2017
Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay ...
P. Brunner, M. Suárez-Fariñas, H. He, K. Malik, H. Wen, Juana Gonzalez, T. Chan, Y. Estrada, Xiuzhong Zheng, S. Khattri, A. Dattola, J. Krueger, E. Guttman‐Yassky   +12 more
semanticscholar   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Identification of tuberculosis-associated proteins in whole blood supernatant

BMC Infectious Diseases, 2011
Background Biological parameters are useful tools for understanding and monitoring complicated disease processes. In this study, we attempted to identify proteins associated with active pulmonary tuberculosis (TB) using a proteomic approach.
Lien Luu, Le Hang Nguyen, Kobayashi Nobuyuki, Kaburagi Yasushi, Hirano Hisashi, Yasuda Kazuki, Takahashi Eri, Kano Keiko, Sakurada Shinsaku, Tanaka Takahiro, Matsushita Ikumi, Hijikata Minako, Uchida Takafumi, Keicho Naoto   +13 more
doaj   +1 more source

Quantification of depletion-induced adhesion of Red Blood Cells [PDF]

, 2012
Red blood cells (RBC) are known to form aggregates in the forms of rouleaux due to the presence of plasma proteins under physiological conditions. Rouleaux formation can be also induced in vitro by the addition of macromolecules to the RBC solution. Current data on the adhesion strength between red blood cells in their natural discocyte shapes mostly ...
arxiv   +1 more source