Results 81 to 90 of about 11,399,320 (390)

Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion

Frontiers in Immunology, 2018
Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness.
Anno Saris, Anno Saris, Ivan Peyron, Pieter F. van der Meer, Tor B. Stuge, Jaap Jan Zwaginga, S. Marieke van Ham, S. Marieke van Ham, S. Marieke van Ham, Anja ten Brinke, Anja ten Brinke   +10 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Predicting molecular docking of per- and polyfluoroalkyl substances to blood protein using generative artificial intelligence algorithm DiffDock

BioTechniques
This study computationally evaluates the molecular docking affinity of various perfluoroalkyl and polyfluoroalkyl substances (PFAs) towards blood proteins using a generative machine-learning algorithm, DiffDock, specialized in protein–ligand blind ...
Dhan Lord B Fortela, Ashley P Mikolajczyk, Miranda R Carnes, Wayne Sharp, Emmanuel Revellame, Rafael Hernandez, William E Holmes, Mark E Zappi   +7 more
doaj   +1 more source

Characterization of blood-derived exosomal proteins after exercise

Journal of International Medical Research, 2020
Objective To assess changes in plasma exosome levels and protein content in mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived ...
Hongkai Xiang, Shisheng Chen, Junhan Zhou, Junxiu Guo, Qingfeng Zhou, Qishuang Zhou   +5 more
doaj   +1 more source

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

BMC Genomics, 2022
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic ...
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu   +6 more
doaj   +1 more source

EFFECT OF DIETARY SUPPLEMENTATION WITH CLOMIPHENE CITRATE ON SOME PRODUCTIVE AND PHYSIOLOGICAL TRAITS OF LAYING JAPANESE QUAIL

The Iraqi Journal of Agricultural science, 2022
This study was conducted to evaluate the effect of supplementation different levels of Clomiphene citrate to the diet of female quail on productive and some physiological traits.
Hasanain N. Ezzat, R. S. Al-Mahdawi, Mohammed A. Hussein, A. S. Al-Hassani   +3 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Proteins and antibodies in serum, plasma, and whole blood—size characterization using asymmetrical flow field-flow fractionation (AF4)

Analytical and Bioanalytical Chemistry, 2018
The analysis of aggregates of therapeutic proteins is crucial in order to ensure efficacy and patient safety. Typically, the analysis is performed in the finished formulation to ensure that aggregates are not present.
M. Leeman, Jaeyeong Choi, S. Hansson, M. U. Storm, L. Nilsson   +4 more
semanticscholar   +1 more source

Dietary Protein and the Blood Glucose Concentration [PDF]

Diabetes, 2013
Body proteins are being synthesized and degraded continuously (1). The estimated turnover is ∼210 g/day (2). Amino acids resulting from protein degradation can be recycled (reused for synthesis), but this is incomplete. Therefore, dietary protein is necessary for maintenance of lean body mass.
Frank Q. Nuttall, Mary C. Gannon
openaire   +3 more sources