Results 61 to 70 of about 4,352,670 (359)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Use of C-reactive protein in pediatric patients with renal diseases

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2017
Background: the use of C-reactive protein as an inflammatory marker in various conditions is part of novel studies in the field of many specialties such as cardiology and immunology.Objective: to assess the usefulness of C-reactive protein for the ...
Elizabeth Vidor Guerra, Martha Socarrás Conde, Kirenia Méndez Amador, Guillermo Rivero Feixas, Oscar Pérez Morales   +4 more
doaj  

Stability of erythrocyte sedimentation in a constant magnetic field [PDF]

, 1989
The stability of erythrocyte sedimentation in the presence of a transverse component of the ponderomotive force is investigated. The processes of erythrocyte aggregation lead to the sedimentation being unstable with respect to small variations of the ...
Kizilova, N.
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Effects of low power violet laser irradiation on red blood cells volume and erythrocyte sedimentation rate in human blood

, 2017
This study is designed in vitro to examine the effects of low power violet laser irradiation on some human blood samples rheological factors such as mean red blood cell volume (MCV) and erythrocyte sedimentation rate (ESR).
M. S. Musawi, M. Jafaar, N. M. Ahmed, B. Al-Gailani, F. Suhaimi   +4 more
semanticscholar   +1 more source

Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela, DI LOLLO, ANNA CHIARA, Gambardella, Lucrezia, Malorni, Walter, Straface, Elisabetta, Valesini, Guido   +5 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Investigating the Relationship between COPD Severity and Inflammatory Markers ESRe and CRP in Hospitalized Patients [PDF]

پزشکی بالینی ابن سینا
Background and Objective: Chronic Obstructive Pulmonary Disease (COPD) is a type of obstructive pulmonary disease that is identified by chronic narrowing of the airways.
Halimeh Aali, Mehrangiz Ghafari, Hossein Pour Masomi, Dadkhoda Sofi, Mohammad Sanchol, Seyed Ali Forghani   +5 more
doaj  

Concentration of white blood cells from whole blood by dual centrifugo-pneumatic siphoning with density gradient medium [PDF]

, 2012
Due to the pervasiveness of HIV infections in developing countries there exists a need for a low-cost, user-friendly point-of-care device which can be used to monitor the concentration of T-lymphocytes in the patient’s blood expressing the CD4+ epitope ...
Ducrée, Jens, Glynn, Macdara, Kearney, Sinead M., Kinahan, David J.   +3 more
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