Results 61 to 70 of about 2,382,321 (284)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

BMC Geriatrics, 2019
Background Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia.
Vera A. van Atteveld, Jeanine M. Van Ancum, Esmee M. Reijnierse, Marijke C. Trappenburg, Carel G. M. Meskers, Andrea B. Maier   +5 more
doaj   +1 more source

Sedimentation of Blood Corpuscles [PDF]

Nature, 1920
I HAVE noticed lately that if oxalated or defibrinated Wood is put to stand in narrow tubes, the corpuscles sediment a good deal faster if the tube is inclined than when it is vertical. Thus with tubes about 2.7 mm. internal diameter there were, after 20 hours, 4, 23, 35, and 42 per cent of clear serum with tubes inclined at 0°, 221/3°, 45°, and 671/2°
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Sedimentation in an artificial lake ‐ lake matahina, bay of plenty [PDF]

, 1981
Lake Matahina, an 8 km long hydroelectric storage reservoir, is a small (2.5 km2), 50 m deep, warm monomictic, gorge‐type lake whose internal circulation is controlled by the inflowing Rangitaiki River which drains a greywacke and acid volcanic catchment.
Christopher J. Phillips, Nelson, Campbell S., Campbell S. Nelson, Phillips, Christopher J.   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Two-phase modeling of batch sedimentation [PDF]

, 1999
A two-phase model for the simulation of sedimentation processes is presented. The model solves the continuity and momentum equations for the pure-clear liquid and the sludge phases, and it is verified against a well-known benchmark problem, for which ...
Markatos, N, Latsa, M, Markatos, N., M. Latsa, A. Stamou B, D. Assimacopoulos A, D. Assimacopoulos, Stamou, A., M. Latsa A, Assimacopoulos, D, N. Markatos A, A. Stamou, Assimacopoulos, D., N. Markatos, Latsa, M., Stamou, A   +15 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Microfluidic Chip for Quantitatively Assessing Hemorheological Parameters

Micromachines
The biomechanical properties of blood are regarded as promising biomarkers for monitoring early-stage abnormalities and disease progression. To detect any changes in blood, it is necessary to measure as many rheological properties as possible.
Yang Jun Kang
doaj   +1 more source