Results 81 to 90 of about 243,326 (311)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

open access: yesAdvanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode   +16 more
wiley   +1 more source

Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquired pneumonia

open access: yesInternational Journal of General Medicine, 2012
Motoi Ugajin, Kenichi Yamaki, Natsuko Iwamura, Takeo Yagi, Takayuki AsanoDepartment of Respiratory Medicine, Ichinomiya-Nishi Hospital, Ichinomiya City, Aichi Prefecture, JapanBackground: Early studies of community-acquired pneumonia showed that ...
Ugajin M   +4 more
doaj  

Nitrogen sources associated with different physical forms of corn grain in the diet for steers in feedlot

open access: yesActa Scientiarum: Animal Sciences, 2018
This study evaluated the substitution of soybean meal with non-protein nitrogen sources, in combination with ground or whole corn for feedlot cattle. Fifty-four Charolais x Nellore steers with 22 ± 0.23 months and 250 ± 15.80 kg were assigned to a 3 x 2 ...
Renata Volpatto Porsch   +5 more
doaj   +1 more source

Studies on the rejection of the transplanted homologous dog liver. [PDF]

open access: yes, 1961
Dogs in which livers have been replaced with hepatic homografts usually die in 5 to 10 days. Liver metabolism is not detectably abnormal at first, but gradual deterioration of function commences on the fourth or fifth day.
BROCK, DR   +3 more
core   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

open access: yesAdvanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li   +19 more
wiley   +1 more source

Nitrogen Metabolism During Hepatectomy and Hyperbaric Oxygenation: Experimental Study

open access: yesОбщая реаниматология, 2007
Objective: to examine nitrogen metabolism in the organs of the portal system during liver resection (LR) and hyperbaric oxygenation (HBO).Material and methods: Experiments were conducted on 65 female albino rats.
P. N. Savilov
doaj   +1 more source

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

open access: yes, 2018
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver ...
Eo, Jinsu   +4 more
core   +1 more source

Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients [PDF]

open access: yes, 2017
BACKGROUND: Colorimetric albumin assays based on binding to bromocresol purple (BCP) and bromocresol green (BCG) yield different results in chronic kidney disease. Altered dye binding of carbamylated albumin has been suggested as a cause.
Delanghe, Joris   +8 more
core   +1 more source

Hydrogel‐Based Functional Materials: Classifications, Properties, and Applications

open access: yesAdvanced Materials Technologies, EarlyView.
Conductive hydrogels have emerged as promising materials for smart wearable devices due to their outstanding flexibility, multifunctionality, and biocompatibility. This review systematically summarizes recent progress in their design strategies, focusing on monomer systems and conductive components, and highlights key multifunctional properties such as
Zeyu Zhang, Zao Cheng, Patrizio Raffa
wiley   +1 more source

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