Results 201 to 210 of about 87,615,486 (243)

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, Volume 38, Issue 55, 1 October 2026.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, Volume 13, Issue 55, 5 October 2026.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Safe and Stable Germline Transmission of MSTN Mutations in Cattle

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT With the global population expected to reach 10 billion by 2050, sustainable livestock production is critical. Gene editing of the myostatin (MSTN) gene represents a promising strategy to enhance muscle growth in cattle. In this study, MSTN‐mutated founder (F0) cows were used to generate F1 offspring via ovum pick‐up, in vitro fertilization ...
Gyeong‐Min Gim, Bae Young Choi, Jeongbin Yi, Kyeong‐Hyeon Eom, Soo‐Young Yum, Dae‐Jin Jung, Do‐Yoon Kim, Bokyoung Yang, Jong‐Seo Kim, Donghwan Shim, Goo Jang   +10 more
wiley   +1 more source

Increased Lymphocyte Proportions as a Candidate Biomarker for Immune‐Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors and Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Combination therapy comprising immune checkpoint inhibitors (ICIs) and chemotherapy is standard treatment for many cancer types. However, the management of adverse events (AEs) induced by combination therapy is more complicated than that of AEs induced by ICI monotherapy.
Nanami Ito, Yoshihiko Tasaki, Yosuke Sugiyama, Takehiro Uemura, Keisuke Yokota, Ryo Ogawa, Takaya Shimura, Daisuke Kawakita, Yumi Wanifuchi‐Endo, Yoshihisa Mimura, Moeko Iida, Kunihiro Odagiri, Yuka Kimura, Misato Tomita, Yuji Hotta, Tatsuya Toyama, Shinichi Iwasaki, Hiromi Kataoka, Shuji Takiguchi, Katsuhiro Okuda, Akio Niimi, Yoko Furukawa‐Hibi   +21 more
wiley   +1 more source

Unusual Hemodynamic Presentation of Pediatric Kikuchi‐Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor‐Dependent Hypotension

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Kikuchi‐Fujimoto disease rarely presents with vasopressor‐dependent hypotension requiring pediatric intensive care despite preserved cardiac function. This case highlights the importance of early excisional lymph node biopsy for timely diagnosis and appropriate management of children with unexplained hemodynamic instability and necrotizing ...
Abdulla Alfraij, Fatma Mothafar, Wasmi Alfadhli, Ali Ashkanani, Lujain A. Kamal, Esmail Redha, Abdulrahman Aldaithan   +6 more
wiley   +1 more source

Pediococcus acidilactici PA53 Supplementation Improves Stool Form and Modulates Gut Microbiota and Inflammatory Responses in Adults With Functional Constipation: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
In this randomized, double‐blind, placebo‐controlled trial, 8‐week supplementation with Pediococcus acidilactici PA53 significantly improved stool form in adults with functional constipation. PA53 supplementation was associated with changes in inflammatory markers and gut microbiota, including increased Pediococcus abundance.
Yuhan Xia, Yongmei Cai, Yongwei Zhang, Rui Cai, Hanshu Liu, Zhiwen Qiang   +5 more
wiley   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

The Fibrosis‐4 Index Predicts Ceftriaxone‐Associated Gallstone Formation: Risk Stratification Using the Fibrosis‐4 Index in a Clinical Cohort

JGH Open, Volume 10, Issue 10, October 2026.
ABSTRACT Background Ceftriaxone is widely used because of its broad antimicrobial spectrum and convenient dosing; however, high biliary excretion can lead to calcium–ceftriaxone precipitation and gallstone‐like formations. Although exposure‐related risk factors have been described, the effect of hepatic fibrosis on ceftriaxone‐associated gallstone ...
Hideo Kato, Mao Hagihara, Hiroshige Mikamo, Takuya Iwamoto   +3 more
wiley   +1 more source

Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial

JGH Open, Volume 10, Issue 10, October 2026.
ABSTRACT Background Ulcerative colitis (UC) is a diffuse, nonspecific inflammation of the colon of unknown cause. Basic and clinical studies suggest that UC may be ameliorated by dietary fiber intake. Fermented brown rice by Aspergillus oryzae (FBRA) is produced by fermenting brown rice and bran with A. oryzae. We aimed to evaluate the efficacy of FBRA
Hideki Ishikawa, Yoshinari Onishi, Keiko Kataoka, Yoshitaka Murakami, Michihiro Mutoh, Hiroshi Kobayashi   +5 more
wiley   +1 more source