Results 81 to 90 of about 87,615,486 (243)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

A suspected case of hypoxia-induced pre-renal azotemia in an old part-Arab stallion: case report and review of the literature

Notulae Scientia Biologicae, 2020
The kidneys maintain homeostasis and this function is compromised in hypoxic conditions. Hematology and serum biochemistry evaluations were performed on a 17-year old Nigerian part-Arab stallion, who was observed to be docile, cachexic, and has bilateral
Onyinyechukwu A. AGINA, Ezinne C. ANI
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Independent prognostic importance of blood urea nitrogen to albumin ratio in critically ill patients with congestive heart failure

Scientific Reports
New studies have revealed an association between chronic heart failure, the severity of septic shock, and the blood urea nitrogen to albumin ratio (BAR).
Jingxiang Yang, Jiuyi Wang, Kai Wang
doaj   +1 more source

Associations between renal tubular lesions and clinical parameters as well as prognosis in diabetic kidney disease

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the associations between renal tubular lesions under light microscope and clinical parameters in diabetic kidney disease （DKD） and provide clinicopathological evidence for adverse progression of DKD patients.MethodsFrom January 2018 ...
Shao Xiao-lin, Luo Yu-qing, Ma Dong-hong, Deng Xi-wen, Guo Ming-hao   +4 more
doaj  

Elevated Blood Urea Nitrogen to Serum Albumin Ratio Is an Adverse Prognostic Predictor for Septic shock in Intensive Care Units

, 2023
Abstract BACKGROUND Septic shock is a life-threatening subset of sepsis, and blood urea nitrogen (BUN) and serum albumin are inexpensive and easily available biomarkers. BUN to serum albumin ratio (BAR) has been identified as a valuable prognostic marker in various diseases.
Hai Hu, Dan He, Minshan Qiu, Wupeng Tan, Lingyan Liu, Shuai Liu, Youqiao Guo, Jun lyu, Haiyan Yin   +8 more
openaire   +1 more source

Effect of urea on warfarin-human serum albumin complex: fluorscence study / Nasim Sakhaei [PDF]

, 2011
In order to evaluate the change in the drug binding ability of human serum albumin (HSA) with the alteration in its native conformation, effect of urea was investigated on the tertiary structure of HSA as well as on its interaction with warfarin, an ...
Sakhaei, Nasim
core  

Elevated Blood Urea Nitrogen-to-Creatinine Ratio Increased the Risk of Hospitalization and All-Cause Death in Patients with Chronic Heart Failure

, 2011
To examine the relationship between blood urea nitrogen (BUN )-to- creatinine ratio and the prognosis of chronic heart failure (HF).We analyzed the data from the cohort of 243 adult patients with chronic HF followed at the HF clinic in a tertiary medical
LIN, HUNG-JU;CHAO, CHIA-LUN;CHIEN, KUO-LIONG;HO, YI-LWUN;LEE, CHII-MING;LIN, YEN-HUNG;WU, YEN-WEN;HSU, RON-BIN;CHOU, NAI-KUAN;WANG, SHOEI-SHEN;CHEN, CHING-YI;CHEN, MING-FONG, 林鴻儒;趙嘉倫;簡國龍;何奕倫;李啟明;林彥宏;吳彥雯;許榮彬;周迺寬;王水深;陳靖宜;陳明豐   +1 more
core   +1 more source

Prognostic impact of blood urea nitrogen to albumin ratio on patients with sepsis: a retrospective cohort study

, 2023
To investigate the ability of the ratio of blood urea nitrogen (BUN) to serum albumin ratio (BAR) in patients with sepsis in intensive care units (ICUs) to predict the prognosis of short-and long-term death.
Lei Hong, Huihui Liu, Shan Gao, Meng Li, Yuhe Wang, Shu Yang, Yong Zhang, Tingting Hou   +7 more
core   +1 more source