Results 101 to 110 of about 87,615,486 (243)

Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality of patients with chronic obstructive pulmonary disease in the intensive care unit: a retrospective cohort study

The Egyptian Journal of Bronchology
Background Blood urea nitrogen to serum albumin ratio (BAR) was found to be a valuable tool for predicting mortality in different diseases. However, few studies have explored the association between BAR and in-hospital mortality in critically ill ...
Rui Ren, Yushan Shi, Yanmei Zhang
doaj   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

POTENTIAL IMPACTS OF PHARMACEUTICAL USES OF TRANSGENIC TOBACCO: THE CASE OF HUMAN SERUM ALBUMIN (HSA) [PDF]

The potential size and distribution of benefits from transgenic tobacco as a source of human serum albumin are estimated using an economic surplus model with imperfect competition.
Kostandini, Genti, Mills, Bradford F., Norton, George W.   +2 more
core  

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016

Environment International, 2019
Background: Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney ...
Ashley J. Malin, Corina Lesseur, Stefanie A. Busgang, Paul Curtin, Robert O. Wright, Alison P. Sanders   +5 more
doaj   +1 more source

Risk prediction of all-cause mortality in hospitalized patients with severe acute pancreatitis by serum urea nitrogen/albumin ratio.

BackgroundClassification of risk levels in patients with acute pancreatitis remains a difficult task. Although some biomarkers have emerged to predict the prognosis of patients with acute pancreatitis, they have not been widely used in clinical practice ...
Ziwen Lv, Xingyu Zhu, Huisi Qiu, Yongshuai Fu, Zhuo Gao, Junhui Gu, Dong Liu   +6 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

EFFECT OF DIALYZER REUSE UPON UREA REDUCTION RATIO (URR), KT/V UREA AND SERUM ALBUMIN IN REGULAR HEMODIALYSIS PATIENT [PDF]

, 2015
Reuse of dialyzers for hemodialysis can help in bringing down the cost of hemodialysis. On the other hand reuse of dialyzer may change dialyzer integrity.
R. Dewi, Ni Made Amelia; Post Graduate Program of Clinical Pharmacy, Airlangga University, 60268, Suprapti, Budi; Department of Clinical Pharmacy, Airlangga University, 60268, Widiana, I Gde Raka; Nephrology Unit, Internal Medicine Department of RSUP Sanglah Denpasar Jalan Diponegoro, Denpasar, Bali 80114   +2 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source