Results 111 to 120 of about 87,615,486 (243)

Association between Blood Urea Nitrogen-to-Serum Albumin Ratio and Cardiovascular Disease Risk: A NHANES Study

Abstract Background Cardiovascular disease (CVD) ranks among the top causes of mortality worldwide, particularly impacting the US. The Blood Urea Nitrogen-to-Serum Albumin Ratio (BAR) has recently been identified as a promising biomarker that integrates indicators of both renal and nutritional health.
Wei Chen, Xinghong Zhou, Bailing Zhang, Yue Wu   +3 more
openaire   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Immunological and Physiological Differences Between Layer- and Broiler Chickens after Concurrent Intratracheal Administration of Lipopolysaccharide and Human Serum Albumin [PDF]

, 2010
Layers and broilers were concurrently intratracheally challenged with 0.5 mg Lipopolysaccharide (LPS) and 0.1 mg Human Serum Albumin (HuSA) at 3 weeks of age.
Lammers, A., Parmentier, H.K., de Vries Reilingh, G., Freke, P., Vries Reilingh, G., de, Koopmanschap, R.E.   +5 more
core  

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Blood urea nitrogen-to-albumin ratio and in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Biomolecules & Biomedicine
In-hospital mortality remains an important concern in patients with ST-elevation myocardial infarction (STEMI), highlighting the need for simple and readily available markers for early risk stratification. This study investigated the prognostic value of
Şükriye Uslu, Ahmet Genç, Gülsüm Meral Yılmaz Öztekin, Görkem Kuş, Şakir Arslan   +4 more
doaj   +1 more source

Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification. [PDF]

, 2009
Crosslinked polystyrene co-divinylbenzene adsorbent microspheres with median diameters between 40 and 300 μm, with an enhanced proportion of mesopores in the range 4–10 nm, have been synthesized using a membrane emulsification technique.
Trochimczuk, Andrzej W., D.J. Malik, Malik, Danish Javed, Chris Webb (7127804), R.G. Holdich, C. Webb, Dale, James A., Iain Roche (7127942), G.L. Warwick, N.A. Hoenich (7128515), G.L. Warwick (7128506), Danish Malik (1254321), Richard Holdich (1253271), J.J. Ramsden (7128503), J.A. Dale (7128512), David Williams (1248024), Warwick, Graham L., Roche, I., Holdich, Richard G., I. Roche, Williams, David John, J.A. Dale, A.W. Trochimczuk, N.A. Hoenich, J.J. Ramsden, D.J. Williams, Hoenich, Nicholas Andrew, Webb, C., Ramsden, Jeremy J., Andrzej W. Trochimczuk (7128509)   +29 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source