Results 101 to 110 of about 899,662 (357)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Identification of a Hemolysis Threshold That Increases Plasma and Serum Zinc Concentration. [PDF]

, 2017
Background: Plasma or serum zinc concentration (PZC or SZC) is the primary measure of zinc status, but accurate sampling requires controlling for hemolysis to prevent leakage of zinc from erythrocytes.
Ghosh, Shibani, Killilea, David W, King, Janet C, Otoo, Gloria E, Rohner, Fabian, Siekmann, Jonathan H, Smith, Lauren   +6 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

An LC-MS/MS Method for Quantification of Lamotrigine and Its Main Metabolite in Dried Blood Spots

Pharmaceuticals
Background: The antiepileptic drug lamotrigine (LTG) shows high pharmacokinetic variability due to genotype influence and concomitant use of glucuronidation inducers and inhibitors, both of which may be frequently taken by elderly patients.
Daniela Milosheska, Robert Roškar, Tomaž Vovk, Bogdan Lorber, Iztok Grabnar, Jurij Trontelj   +5 more
doaj   +1 more source

Predicting optimal hematocrit in silico [PDF]

, 2018
Optimal hematocrit $H_o$ maximizes oxygen transport. In healthy humans, the average hematocrit $H$ is in the range of 40-45$\%$, but it can significantly change in blood pathologies such as severe anemia (low $H$) and polycythemia (high $H$). Whether the
Audemar, Vassanti, Benyoussef, Abdelilah, Coupier, Gwennou, Ez-Zahraouy, Hamid, Farutin, Alexander, Harting, Jens, Misbah, Chaouqi, Podgorski, Thomas, Polack, Benoit, Prado, Gael, Shen, Zaiyi, Vlahovska, Petia M.   +11 more
core   +7 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

THE DETERMINATION OF THE CIRCULATING BLOOD VOLUME IN INFANTS BY THE CARBON MONOXIDE METHOD [PDF]

, 1929
R. McIntosh
openalex   +1 more source

Ligand-Receptor Interactions

, 2008
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems.
Alder B J, Alon R, Amit A G, André P, Antosiewicz J, Ashkin A, Atherton A, Atherton A, Balsera M, Beeson C, Bell G I, Bell G I, Berg H C, Berg H C, Bhat T N, Boland T, Bongrand P, Bongrand P, Brady G P, Brooks B R, Brune D, Brunk D K, Böhm H J, Böhm H J, Cantor C R, Capo C, Chesla S E, Chilkoti A, Choquet D, Chu L, Clackson T, Claesson P M, Collins F C, Connelly P R, Creighton T E, Creighton T E, Curtis A S G, Danmer U, Danmer U, Debye P, deLisi C, Dembo M, Dustin M L, Eisenberg D, Eisenberg D, Erlandsson R, Ermak D L, Evans E, Evans E, Evans E A, Evans E A, Evans E A, Evans E A, Evans E A, Eyring H, Eyring H, Fersht A, Florin E L, Gabdouline R R, Garboczi D N, Gilson M K, Goldsmith H L, Grubmüller H, Grutter M G, Hammer D A, Hammer D A, Helm C, Hill T L, Hirschefelder J O, Hoh J H, Honig B, Israelachvili J N, Israelachvili J N, Israelachvili J N, Izrailev S, Jencks W P, Jorgensen W L, Jorgensen W L, Kabat E A, Kaplanski G, Karplus M, Kishino A, Kozack R E, Kramers H A, Kuo S C, Kupfer A, Kwong D, Lawrence M B, Lawrence M B, Leckband D E, Leckband D E, Lee B, Lee C Y, Lee G U, Liebert R B, Lollo B A, London F, Maitland G C, Margenau H, Marston S B, Martorana V, McClay D R, McCloskey M A, Merkel R, Metropolis M, Meyhöfer E, Miyamoto S, Moy V T, Nishizaka T, Northrup S H, Northrup S H, Ooi T, Page M J, Palecek S P, Pangali C, Patel K D, Pauling L, Pierres A, Pierres A, Pierres A, Piper J W, Pratt L R, Richards F F, Richards F M, Rossky P J, Sato M, Schmid-Schöenbein G W, Schoup D, Schreiber G, Schuster P, Schwartz L, Smith S B, Sommerfeld A, Sommerfeld A, Steward M W, Stone S R, Stossel T P, Strick T R, Sturtevant J M, Szabo A, Szabo A, Szczesniak M M, Tees D F, Tha S P, Tsao Y H, Tulip W R, Vajda S, Valentine R C, van der Merwe P A, Vinckier A, von Andrian U H, von Fuchs, von Smoluchowski M, Voss Jr E W, Weast R C, Weber P C, Williams A-F, Winter C C, Wurmser R, Zurkhov S N   +159 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Hyperglycemia Is Associated With Computed Tomography Perfusion Core Volume Underestimation in Patients With Acute Ischemic Stroke With Large‐Vessel Occlusion

Stroke: Vascular and Interventional Neurology
Background Computed tomography perfusion (CTP) predictions of infarct core play an important role in the determination of treatment eligibility in large‐vessel occlusion acute ischemic stroke. Prior studies have demonstrated that blood glucose can affect
Arash Niktabe, Juan Carlos Martinez‐Gutierrez, Sergio Salazar‐Marioni, Rania Abdelkhaleq, Juan Carlos Rodriguez Quintero, Jerome A. Jeevarajan, Muhammad Bilal Tariq, Ananya S. Iyyangar, Hussain M. Azeem, Anjan Nagesh Ballekere, Ngoc Mai Le, Louise D. McCullough, Sunil A. Sheth, Youngran Kim   +13 more
doaj   +1 more source