A comparison of methods for determining ploidy in white sturgeon (Acipenser transmontanus) [PDF]
, 2019 Release of sturgeon with abnormal ploidy into the wild may result in reduced fitness due to lowered fertility in the F2 and subsequent generations. Further, there is evidence that ploidy affects reproductive development and caviar yield.
Fiske, JA +6 more
core
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
BMC Nephrology, 2019 Background Volume overload and depletion both lead to high morbidity and mortality. Achieving euvolemia is a challenge in patients with end stage kidney disease on hemodialysis (HD).
Line Malha +3 more
doaj +1 more source
Comparative analysis of parameters of oxygenation, ventilation and acid-base status during intraoperative application of conventional and protective lung ventilation [PDF]
Praxis Medica, 2015 The aim of this study was to perform a comparative analysis applied conventional (traditional) and protective mechanical lung ventilation in clinical conditions with regard to intraoperative parameters changes of oxygenation, ventilation and acid-base ...
Videnović N. +6 more
doaj +1 more source
The use of invasive techniques, angiography and indicator dilution, for quantification of valvular regurgitations [PDF]
, 2017 Angiographic techniques have been used for the quantification of mitral or aortic and rarely tricuspid regurgitation. Mitral or aortic regurgitant volume per beat and the regurgitation fraction (fao and fm, respectively) are obtained from the ...
Hess, O. M. +3 more
core
Estimated central blood volume in cirrhosis [PDF]
, 1992 The estimated central blood volume (i.e., blood volume in the heart cavities, lungs and central arterial tree) was determined by multiplying cardiac output by circulatory mean transit time in 19 patients with cirrhosis and compared with sympathetic ...
Arendt +39 more
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Mechanisms underlying the volume regulation of interstitial fluid by capillaries: a simulation study
Integrative Medicine Research, 2016 Background: Control of the extracellular fluid volume is one of the most indispensable issues for homeostasis of the internal milieu. However, complex interdependence of the pressures involved in determination of fluid exchange makes it difficult to ...
Yukiko Himeno +4 more
doaj +1 more source
A determination of the blood and plasma volume of dairy cattle : a study of blood and plasma volume during growth, pregnancy, and lactation [PDF]
, 1931 Publication authorized July 17, 1931."The data presented in this paper formed part of a thesis presented by H.A. Herman in partial fulfillment of the requirements for the Degree of Master of Arts in the Graduate School of the University of Missouri, 1931"
Herman, Harry August, 1905- +1 more
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source