Results 91 to 100 of about 3,791,267 (292)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Dark Side of the Universe: Doppler Shift [PDF]
This activity illustrates the Doppler effect in cosmology by use of rubber bands. Students will learn how light waves emitted from stars are red shifted if the stars are moving away from Earth (light waves are stretched, producing longer wavelengths ...
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Blue Light Therapy: A Skin Treatment Mask using Blue Light to cure Skin Disorders
Sukkur IBA Journal of Emerging TechnologiesSkin acne and disease are the most common medical conditions that lead from mild to moderate if not treated in time. There are several treatments such as Chemical peel, Dermabrasion, and many others these hyped techniques have proven to be extremely ...
Aleena Kamal +5 more
doaj +1 more source
Dynamics of two atoms undergoing light-assisted collisions in an optical microtrap
, 2013 We study the dynamics of atoms in optical traps when exposed to laser cooling light that induces light-assisted collisions. We experimentally prepare individual atom pairs and observe their evolution.
Andersen, M. F. +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Microalgae-based dosimetry for monitoring blue light exposure
Applied PhycologyBlue light therapy is increasingly used to treat various skin conditions like acne, psoriasis and neonatal hyperbilirubinemia. Yet, excessive blue light exposure can also negatively impact human health by disrupting circadian rhythms, generating free ...
Léa Habib +5 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source