Results 91 to 100 of about 3,699,197 (346)

RGB generation by four-wave mixing in small-core holey fibers

, 2007
We report the generation of white light comprising red, green, and blue spectral bands from a frequency-doubled fiber laser by an efficient four-wave mixing process in submicron-sized cores of microstructured holey fibers.
Horak, P., Dupriez, P., Poletti, F., Petrovich, M.N., Jeong, Y., Nilsson, J., Richardson, D.J., Payne, D.N.   +7 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

The absolute infrared magnitudes of type Ia supernovae

, 2000
The absolute luminosities and homogeneity of early-time infrared (IR) light curves of type Ia supernovae are examined. Eight supernovae are considered.
Branch D., Bureau M., Cardelli J. A., Ciardullo R., Elias J. H., Elias J. H., Ferrarese L., Fisher A., Ford C. H., Freedman W. L., Frogel J. A., Gibson B. K., Graham J. R., Hamuy M., Hamuy M., Hamuy M., Hamuy M., Hernandez M., Hoflich P., Jha S., Kirshner R. P., Leibundgut B., Lira P., Madore B. F., Meikle W. P. S., Meikle W. P. S., Phillips M. M., Phillips M. M., Phillips M. M., Poggianti B. M., Pskovskii Y. P., Pskovskii Y. P., Riess A. G., Riess A. G., Saha A., Shaefer B. E., Spyromilio J., Tripp R., W. P. S. Meikle, Wells L. A., Wheeler J. C.   +40 more
core   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Microalgae-based dosimetry for monitoring blue light exposure

Applied Phycology
Blue light therapy is increasingly used to treat various skin conditions like acne, psoriasis and neonatal hyperbilirubinemia. Yet, excessive blue light exposure can also negatively impact human health by disrupting circadian rhythms, generating free ...
Léa Habib, Jihane Rahbani Mounsef, Rime Michael-Jubeli, Marie Abboud, Ali Tfayli, Roger Lteif   +5 more
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Blue Light Therapy: A Skin Treatment Mask using Blue Light to cure Skin Disorders

Sukkur IBA Journal of Emerging Technologies
Skin acne and disease are the most common medical conditions that lead from mild to moderate if not treated in time. There are several treatments such as Chemical peel, Dermabrasion, and many others these hyped techniques have proven to be extremely ...
Aleena Kamal, Minahil Kamal, Bushra Mehboob, Tayaba Naz, Shoaib Zafar, Syed Muddusir Hussain   +5 more
doaj   +1 more source