Results 91 to 100 of about 1,319,206 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The water footprint of electricity from hydropower [PDF]

, 2011
Hydropower accounts for about 16% of the world’s electricity supply. Although dams often have big environmental and social impacts, proponents of hydropower regard it as a comparatively clean, low-cost and renewable form of energy.
M. M. Mekonnen, Hoekstra, Arjen Ysbert, A. Y. Hoekstra, Mekonnen, Mesfin   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Accounting and Evolution of Global Spatial Explicit Blue and Green Water Footprint of Maize Production With Fewer Inputs

Water Resources Research
Gridded data updating for crop water consumption differentiating blue (i.e., irrigation water) and green (i.e., soil water) components at global scale is too hysteretic because of heavy working load and time cost of physical‐based models to prompt ...
Yilin Liu, La Zhuo, Xiangxiang Ji, Pengcheng Tian, Rong Gao, Pute Wu   +5 more
doaj   +1 more source

Water footprint in multi-scale intensive pig production systems in Argentina: implications for the supply chain of products with designation of origin

Frontiers in Sustainability
Livestock production accounts for a substantial share of global water use, primarily through feed cultivation. Global demand and production of meat continue to increase, driven by income growth and changing dietary preferences.
Santiago Hernán Silva, Santiago Hernán Silva, María Macarena Arrien, María Macarena Arrien, Nicolás Eloy Cisneros Basualdo, Nicolás Eloy Cisneros Basualdo, Camila Touriñan, Camila Touriñan, Maite M. Aldaya, Maite M. Aldaya, Corina Iris Rodríguez, Corina Iris Rodríguez   +11 more
doaj   +1 more source

Water-efficient genotypes along with conservation measures significantly reduce the green and blue water footprints in sugarcane (Saccharum spp.). [PDF]

Sci Rep, 2023
Tayade AS, Vasantha S, Anusha S, Kumar RA, Hemaprabha G, Geetha P, Krishnapriya V, Reddy KS, Bhatt R, Siddiqui MH, Kesawat MS.   +10 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Author Correction: Water-efficient genotypes along with conservation measures significantly reduce the green and blue water footprints in sugarcane (Saccharum spp.). [PDF]

Sci Rep, 2023
Tayade AS, Vasantha S, Anusha S, Kumar RA, Hemaprabha G, Geetha P, Krishnapriya V, Reddy KS, Bhatt R, Siddiqui MH, Kesawat MS.   +10 more
europepmc   +1 more source

Blue Hole entrance postcard [PDF]

, 1940
Postcard depicting the entrance to the Blue Hole in Castalia, Ohio. The Blue Hole is a large spring fed by an underground river. The depth of the Blue Hole is unknown.
E. B. Ackley
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source