Results 111 to 120 of about 1,319,206 (306)
Blue-green infrastructure - perspectives on water quality benefits [PDF]
, 2019 Blue-green infrastructure (BGI) can be defined as a strategic network of natural and manmade green and blue spaces that sustain natural processes. BGI is designed and managed as a multi-functional resource, capable of delivering a wide range of benefits ...
A Sleigh (13383024) +7 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Does food trade save water?: the potential role of food trade in water scarcity mitigation [PDF]
, 2014 This Water Policy Briefing is based on the CA Research Report 4: Does International Cereal Trade Save Water? The Impact of Virtual Water Trade on Global Water Use (CA Research Report 4) by Charlotte de Fraiture, Ximing Cai, Upali Amarasinghe, Mark ...
International Water Management Institute
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
NRS-18381 | Reports of the Water and Sewerage Engineer [Blue Mountains County Council] [PDF]
<p>These are monthly reports of the Water and Sewerage Engineer to the Blue Mountains County Council.</p><p>The Blue Mountains County Council and its committees became defunct in 1947 with the amalgamation of the Blackheath, Katoomba ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Performance of three types of laundry detergents in soft and hard water [PDF]
, 1987 This study was designed to evaluate the performance of current formulations of three types of laundry detergents in soft (60 ppm) and hard (172 ppm) water using home laundry equipment.
Hinkle, Dennis E. +4 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Economical genotyping of little blue penguin (Eudyptula minor) clades from feather-based DNA [PDF]
, 2013 Determination of clade membership is a crucial requirement for many research questions addressing phylogeography, population structure, mating patterns, speciation, and hybridisation.
Clark, Alan J. +2 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source